Anti-NOXO1 Antibody (CAB10477)
- SKU:
- CAB10477
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NOXO1 Antibody |
| Antibody SKU: | CAB10477 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 121-370 of human NOXO1 (NP_653204.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse small intestine, Mouse stomach |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 121-370 of human NOXO1 (NP_653204.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QPLD LEPA LPPG SRVI LPTP EEQP LSRA AGRL SIHS LEAQ SLRC LQPF CTQD TRDR PFQA QAQE SLDV LLRH PSGW WLVE NEDR QTAW FPAP YLEE AAPG QGRE GGPS LGSS GPQF CASR AYES SRAD ELSV PAGA RVRV LETS DRGW WLCR YGDR AGLL PAVL LRPE GLGA LLSG TGFR GGDD PAGE ARGF PEPS QATA PPPT VPTR PSPG AIQS RCCT VTRR ALER RPRR QGRP RGCV DSVP HPTT EQ |
| Gene ID: | 124056 |
| Uniprot: | Q8NFA2 |
| Cellular Location: | Cell membrane, Cytoplasmic side, Peripheral membrane protein |
| Calculated MW: | 40kDa/41kDa |
| Observed MW: | 41kDa |
| Synonyms: | NOXO1, P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28 |
| Background: | This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | NOXO1: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: NADPH oxidase complex; plasma membrane Molecular Function:enzyme binding; identical protein binding; phospholipid binding; protein binding; superoxide-generating NADPH oxidase activator activity Biological Process: extracellular matrix disassembly; regulation of hydrogen peroxide metabolic process |
| NCBI Summary: | This gene encodes an NADPH oxidase (NOX) organizer, which positively regulates NOX1 and NOX3. The protein contains a PX domain and two SH3 domains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012] |
| UniProt Code: | Q8NFA2 |
| NCBI GenInfo Identifier: | 74751269 |
| NCBI Gene ID: | 124056 |
| NCBI Accession: | Q8NFA2.1 |
| UniProt Secondary Accession: | Q8NFA2,Q86YM1, Q8NFA3, Q96B73, |
| UniProt Related Accession: | Q8NFA2 |
| Molecular Weight: | 40,668 Da |
| NCBI Full Name: | NADPH oxidase organizer 1 |
| NCBI Synonym Full Names: | NADPH oxidase organizer 1 |
| NCBI Official Symbol: | NOXO1 |
| NCBI Official Synonym Symbols: | SNX28; P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5 |
| NCBI Protein Information: | NADPH oxidase organizer 1 |
| UniProt Protein Name: | NADPH oxidase organizer 1 |
| UniProt Synonym Protein Names: | NADPH oxidase regulatory protein; Nox organizer 1; Nox-organizing protein 1; SH3 and PX domain-containing protein 5 |
| Protein Family: | NADPH oxidase organizer |
| UniProt Gene Name: | NOXO1 |
| UniProt Entry Name: | NOXO1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NOXO1 antibody (CAB10477) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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