| Background: | This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. |
| UniProt Protein Function: | NOD1: Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Homodimer. Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction. Interacts with ARHGEF2. Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7p14.3 Cellular Component: basolateral plasma membrane; cytoplasm; cytosol Molecular Function:CARD domain binding; caspase activator activity; identical protein binding; peptidoglycan binding; protein binding; protein homodimerization activity Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; apoptosis; caspase activation; defense response; defense response to bacterium; detection of bacterium; detection of biotic stimulus; inflammatory response; interleukin-8 biosynthetic process; JNK cascade; positive regulation of caspase activity; positive regulation of dendritic cell antigen processing and presentation; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein oligomerization; signal transduction |
| NCBI Summary: | This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9Y239 |
| NCBI GenInfo Identifier: | 20137579 |
| NCBI Gene ID: | 10392 |
| NCBI Accession: | Q9Y239.1 |
| UniProt Secondary Accession: | Q9Y239,Q549U4, Q8IWF5, B4DTU3, |
| UniProt Related Accession: | Q9Y239 |
| Molecular Weight: | 27,949 Da |
| NCBI Full Name: | Nucleotide-binding oligomerization domain-containing protein 1 |
| NCBI Synonym Full Names: | nucleotide binding oligomerization domain containing 1 |
| NCBI Official Symbol: | NOD1 |
| NCBI Official Synonym Symbols: | CARD4; NLRC1; CLR7.1 |
| NCBI Protein Information: | nucleotide-binding oligomerization domain-containing protein 1 |
| UniProt Protein Name: | Nucleotide-binding oligomerization domain-containing protein 1 |
| UniProt Synonym Protein Names: | Caspase recruitment domain-containing protein 4 |
| Protein Family: | Nucleotide-binding oligomerization domain-containing protein |
| UniProt Gene Name: | NOD1 |
| UniProt Entry Name: | NOD1_HUMAN |
