Anti-NMU Antibody (CAB7068)
- SKU:
- CAB7068
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NMU Antibody |
| Antibody SKU: | CAB7068 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-174 of human NMU (NP_006672.1). |
| Application: | IHC |
| Recommended Dilution: | IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-174 of human NMU (NP_006672.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ACRG APIL PQGL QPEQ QLQL WNEI DDTC SSFL SIDS QPQA SNAL EELC FMIM GMLP KPQE QDEK DNTK RFLF HYSK TQKL GKSN VVSS VVHP LLQL VPHL HERR MKRF RVDE EFQS PFAS QSRG YFLF RPRN GRRS AGFI |
| Gene ID: | 10874 |
| Uniprot: | P48645 |
| Cellular Location: | Secreted |
| Calculated MW: | 19kDa |
| Observed MW: |
| Synonyms: | NMU |
| Background: | This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. |
| UniProt Protein Function: | NMU: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. Belongs to the NmU family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q12 Cellular Component: extracellular region; terminal button Molecular Function:neuromedin U receptor binding; protein binding; receptor binding Biological Process: digestion; eating behavior; G-protein coupled receptor protein signaling pathway; gastric acid secretion; neuropeptide signaling pathway; photoperiodism; positive regulation of hormone secretion; positive regulation of smooth muscle contraction; positive regulation of synaptic transmission; regulation of smooth muscle contraction; sensory perception of pain; signal transduction |
| NCBI Summary: | This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P48645 |
| NCBI GenInfo Identifier: | 1346685 |
| NCBI Gene ID: | 10874 |
| NCBI Accession: | P48645.1 |
| UniProt Secondary Accession: | P48645,P12760, |
| UniProt Related Accession: | P48645 |
| Molecular Weight: | 19,741 Da |
| NCBI Full Name: | Neuromedin-U |
| NCBI Synonym Full Names: | neuromedin U |
| NCBI Official Symbol: | NMU |
| NCBI Protein Information: | neuromedin-U |
| UniProt Protein Name: | Neuromedin-U |
| Protein Family: | Neuromedin |
| UniProt Gene Name: | NMU |
| UniProt Entry Name: | NMU_HUMAN |
 | Immunohistochemistry of paraffin-embedded human liver using NMU antibody (CAB7068) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophagus using NMU antibody (CAB7068) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using NMU antibody (CAB7068) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using NMU antibody (CAB7068) at dilution of 1:100 (40x lens). |
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