| UniProt Protein Function: | NME2: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Belongs to the NDK family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; EC 2.7.13.3; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; Kinase, nucleoside diphosphate; Kinase, other; EC 2.7.4.6; Other group; NDK family Chromosomal Location of Human Ortholog: 17q21.3 Cellular Component: cytoplasm; cytosol; focal adhesion; lamellipodium; nucleus; ruffle Molecular Function:nucleoside diphosphate kinase activity; protein binding; transcription factor activity Biological Process: cell adhesion; integrin-mediated signaling pathway; negative regulation of apoptosis; nucleobase, nucleoside and nucleotide interconversion; nucleoside triphosphate biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; purine nucleotide metabolic process; pyrimidine nucleotide metabolic process; regulation of epidermis development; regulation of transcription, DNA-dependent |
| NCBI Summary: | Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010] |
| UniProt Code: | P22392 |
| NCBI GenInfo Identifier: | 127983 |
| NCBI Gene ID: | 4831 |
| NCBI Accession: | P22392.1 |
| UniProt Secondary Accession: | P22392,Q1WM23, Q6LCT6, A8MWA3, |
| UniProt Related Accession: | P22392 |
| Molecular Weight: | 30,137 Da |
| NCBI Full Name: | Nucleoside diphosphate kinase B |
| NCBI Synonym Full Names: | NME/NM23 nucleoside diphosphate kinase 2 |
| NCBI Official Symbol: | NME2 |
| NCBI Official Synonym Symbols: | PUF; NDKB; NDPKB; NM23B; NDPK-B; NM23-H2 |
| NCBI Protein Information: | nucleoside diphosphate kinase B |
| UniProt Protein Name: | Nucleoside diphosphate kinase B |
| UniProt Synonym Protein Names: | C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB (EC:2.7.13.3); nm23-H2 |
| UniProt Gene Name: | NME2 |
| UniProt Entry Name: | NDKB_HUMAN |
