Anti-NLRP12 Antibody (CAB14519)
- SKU:
- CAB14519
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NLRP12 Antibody |
| Antibody SKU: | CAB14519 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 862-1062 of human NLRP12 (NP_001264055.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 862-1062 of human NLRP12 (NP_001264055.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LWLK ICRL TAAA CDEL ASTL SVNQ SLRE LDLS LNEL GDLG VLLL CEGL RHPT CKLQ TLRL GICR LGSA ACEG LSVV LQAN HNLR ELDL SFND LGDW GLWL LAEG LQHP ACRL QKLW LDSC GLTA KACE NLYF TLGI NQTL TDLY LTNN ALGD TGVR LLCK RLSH PGCK LRVL WLFG MDLN KMTH SRLA ALRV TKPY LDIG C |
| Gene ID: | 91662 |
| Uniprot: | P59046 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 31kDa/101kDa/107kDa/113kDa/114kDa/120kDa |
| Observed MW: | 120kDa |
| Synonyms: | NLRP12, CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2 |
| Background: | This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | NLRP12: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK. Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2). FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold. Belongs to the NLRP family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19q13.42 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding Biological Process: inhibition of NF-kappaB transcription factor; negative regulation of cytokine secretion; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of inflammatory response; negative regulation of interleukin-1 secretion; negative regulation of interleukin-6 biosynthetic process; negative regulation of protein amino acid autophosphorylation; negative regulation of signal transduction; negative regulation of Toll signaling pathway; positive regulation of MHC class I biosynthetic process; regulation of caspase activity; regulation of I-kappaB kinase/NF-kappaB cascade; release of cytoplasmic sequestered NF-kappaB Disease: Familial Cold Autoinflammatory Syndrome 2 |
| NCBI Summary: | This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
| UniProt Code: | P59046 |
| NCBI GenInfo Identifier: | 34223733 |
| NCBI Gene ID: | 91662 |
| NCBI Accession: | P59046.2 |
| UniProt Secondary Accession: | P59046,Q8NEU4, Q9BY26, A8MTQ2, B3KTE7, |
| UniProt Related Accession: | P59046 |
| Molecular Weight: | 120,329 Da |
| NCBI Full Name: | NACHT, LRR and PYD domains-containing protein 12 |
| NCBI Synonym Full Names: | NLR family pyrin domain containing 12 |
| NCBI Official Symbol: | NLRP12 |
| NCBI Official Synonym Symbols: | RNO; PAN6; RNO2; FCAS2; NALP12; PYPAF7; CLR19.3 |
| NCBI Protein Information: | NACHT, LRR and PYD domains-containing protein 12 |
| UniProt Protein Name: | NACHT, LRR and PYD domains-containing protein 12 |
| UniProt Synonym Protein Names: | Monarch-1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide |
| Protein Family: | NACHT, LRR and PYD domains-containing protein |
| UniProt Gene Name: | NLRP12 |
| UniProt Entry Name: | NAL12_HUMAN |
 | Western blot analysis of extracts of rat spleen, using NLRP12 antibody (CAB14519) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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