Anti-NKX3-2 Antibody (CAB8093)

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SKU:
CAB8093
Product type:
Antibody
Application:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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Antibody Name:NKX3-2 Rabbit Polyclonal Antibody
Antibody SKU:CAB8093
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human NKX3-2 (NP_001180.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human NKX3-2 (NP_001180.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAVR GANT LTSF SIQA ILNK KEER GGLA APEG RPAP GGTA ASVA AAPA VCCW RLFG ERDA GALG GAED SLLA SPAG TRTA AGRT AESP EGWD SDSA LSEE NESR RRCA DARG ASGA GLAG GSLS LGQP VCEL AASK DLEE EAAG RSDS EMSA SVSG DRSP RTED DGVG PRGA HVSA LCSG
Gene ID:579
Uniprot:P78367
Cellular Location:Nucleus
Calculated MW:34kDa
Observed MW:35kDa
Synonyms:NKX3-2, BAPX1, NKX3.2, NKX3B, SMMD
Background:This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development.
UniProt Protein Function:NKX3-2: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Defects in NKX3-2 are the cause of spondylo- megaepiphyseal-metaphyseal dysplasia (SMMD). It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet. Belongs to the NK-3 homeobox family.
UniProt Protein Details:

Protein type:DNA-binding; Cell development/differentiation; Transcription factor

Chromosomal Location of Human Ortholog: 4p16.3

Biological Process: negative regulation of chondrocyte differentiation; skeletal development; transcription from RNA polymerase II promoter

Disease: Spondylo-megaepiphyseal-metaphyseal Dysplasia

NCBI Summary:This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]
UniProt Code:P78367
NCBI GenInfo Identifier:6016210
NCBI Gene ID:579
NCBI Accession:P78367.2
UniProt Secondary Accession:P78367,Q2M2I7,
UniProt Related Accession:P78367
Molecular Weight:34,814 Da
NCBI Full Name:Homeobox protein Nkx-3.2
NCBI Synonym Full Names:NK3 homeobox 2
NCBI Official Symbol:NKX3-2  
NCBI Official Synonym Symbols:SMMD; BAPX1; NKX3B; NKX3.2  
NCBI Protein Information:homeobox protein Nkx-3.2
UniProt Protein Name:Homeobox protein Nkx-3.2
UniProt Synonym Protein Names:Bagpipe homeobox protein homolog 1; Homeobox protein NK-3 homolog B
Protein Family:Homeobox protein
UniProt Gene Name:NKX3-2  
UniProt Entry Name:NKX32_HUMAN
Anti-NKX3-2 Polyclonal Antibody (CAB8093)Western blot analysis of extracts of 293T cells, using NKX3-2 antibody (CAB8093) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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