Anti-NKX2-2 Antibody (CAB16696)

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SKU:
CAB16696
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
Frequently bought together:

Description

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Antibody Name:Anti-NKX2-2 Antibody
Antibody SKU:CAB16696
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human NKX2-2 (NP_002500.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:mouse brain, C6, rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human NKX2-2 (NP_002500.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSLT NTKT GFSV KDIL DLPD TNDE EGSV AEGP EEEN EGPE PAKR AGPL GQGA LDAV QSLP LKNP FYDS SDNP YTRW LAST EGLQ YSLH GLAA GAPP QDSS SKSP EPSA DESP DNDK ETPG GGGD AGKK RK
Gene ID:4821
Uniprot:O95096
Cellular Location:
Calculated MW:30kDa
Observed MW:38kDa
Synonyms:NKX2-2, NKX2.2, NKX2B
Background:The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
UniProt Protein Function:NKX2-2: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter. Belongs to the NK-2 homeobox family.
UniProt Protein Details:

Protein type:Cell development/differentiation; Transcription factor

Chromosomal Location of Human Ortholog: 20p11.22

Cellular Component: nucleoplasm

Molecular Function:chromatin binding; transcription coactivator activity

Biological Process: brain development; endocrine pancreas development; positive regulation of transcription factor activity

NCBI Summary:The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]
UniProt Code:O95096
NCBI GenInfo Identifier:6016205
NCBI Gene ID:4821
NCBI Accession:O95096.1
UniProt Related Accession:O95096
Molecular Weight:30,133 Da
NCBI Full Name:Homeobox protein Nkx-2.2
NCBI Synonym Full Names:NK2 homeobox 2
NCBI Official Symbol:NKX2-2  
NCBI Official Synonym Symbols:NKX2B; NKX2.2  
NCBI Protein Information:homeobox protein Nkx-2.2
UniProt Protein Name:Homeobox protein Nkx-2.2
UniProt Synonym Protein Names:Homeobox protein NK-2 homolog B
Protein Family:Homeobox protein
UniProt Gene Name:NKX2-2  
UniProt Entry Name:NKX22_HUMAN
Anti-NKX2-2 Antibody (CAB16696)Western blot analysis of extracts of various cell lines, using NKX2-2 antibody (CAB16696) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5min.

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