| Background: | Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008] |
| UniProt Protein Function: | ASAH2: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract. Belongs to the neutral ceramidase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - sphingolipid; EC 3.5.1.23; Hydrolase; Membrane protein, integral Chromosomal Location of Human Ortholog: 10q11.21 Cellular Component: mitochondrion Biological Process: ceramide metabolic process; signal transduction |
| NCBI Summary: | Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9NR71 |
| NCBI GenInfo Identifier: | 110832757 |
| NCBI Gene ID: | 56624 |
| NCBI Accession: | Q9NR71.2 |
| UniProt Secondary Accession: | Q9NR71,Q3KNU1, Q5SNT7, Q5SZP6, Q5SZP7, Q5T1D5, Q71ME6 |
| UniProt Related Accession: | Q9NR71 |
| Molecular Weight: | 81,718 Da |
| NCBI Full Name: | Neutral ceramidase |
| NCBI Synonym Full Names: | N-acylsphingosine amidohydrolase 2 |
| NCBI Official Symbol: | ASAH2 |
| NCBI Official Synonym Symbols: | HNAC1; BCDase; LCDase; NCDase; N-CDase |
| NCBI Protein Information: | neutral ceramidase |
| UniProt Protein Name: | Neutral ceramidase |
| UniProt Synonym Protein Names: | Acylsphingosine deacylase 2; BCDase; LCDase; hCD |
| Protein Family: | Neutral ceramidase |
| UniProt Gene Name: | ASAH2 |
| UniProt Entry Name: | ASAH2_HUMAN |
