Anti-NELL1 Antibody (CAB10358)

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SKU:
CAB10358
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
Frequently bought together:

Description

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Antibody Name:Anti-NELL1 Antibody
Antibody SKU:CAB10358
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 160-420 of human NELL1 (NP_006148.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, 293T, Mouse pancreas, Rat brain, Rat small intestine
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 160-420 of human NELL1 (NP_006148.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HLLL HVDC NRIY ERVI DPPD TNLP PGIN LWLG QRNQ KHGL FKGI IQDG KIIF MPNG YITQ CPNL NHTC PTCS DFLS LVQG IMDL QELL AKMT AKLN YAET RLSQ LENC HCEK TCQV SGLL YRDQ DSWV DGDH CRNC TCKS GAVE CRRM SCPP LNCS PDSL PVHI AGQC CKVC RPKC IYGG KVLA EGQR ILTK SCRE CRGG VLVK ITEM CPPL NCSE KDHI LPEN QCCR VCRG HNFC AEGP KCGE NSEC KNWN TKAT CECK S
Gene ID:4745
Uniprot:Q92832
Cellular Location:Cytoplasm, Nucleus envelope, Secreted
Calculated MW:84kDa/89kDa
Observed MW:80kDa
Synonyms:NELL1, IDH3GL, NRP1
Background:This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:NELL1: Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: cytoplasm; nuclear envelope; perinuclear region of cytoplasm

Molecular Function:protein binding

Biological Process: negative regulation of osteoblast proliferation; nervous system development; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; regulation of gene expression

NCBI Summary:This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
UniProt Code:Q92832
NCBI GenInfo Identifier:311033486
NCBI Gene ID:4745
NCBI Accession:Q92832.4
UniProt Secondary Accession:Q92832,Q4VB90, Q4VB91, Q6NSY8, Q9Y472, B2CKC1,
UniProt Related Accession:Q92832
Molecular Weight:84,377 Da
NCBI Full Name:Protein kinase C-binding protein NELL1
NCBI Synonym Full Names:neural EGFL like 1
NCBI Official Symbol:NELL1  
NCBI Official Synonym Symbols:NRP1; IDH3GL  
NCBI Protein Information:protein kinase C-binding protein NELL1
UniProt Protein Name:Protein kinase C-binding protein NELL1
UniProt Synonym Protein Names:NEL-like protein 1; Nel-related protein 1
Protein Family:Protein kinase C-binding protein
UniProt Gene Name:NELL1  
UniProt Entry Name:NELL1_HUMAN
Anti-NELL1 Antibody (CAB10358)Western blot analysis of extracts of various cell lines, using NELL1 antibody (CAB10358) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.

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