Anti-NDUFA10 Antibody (CAB10123)
- SKU:
- CAB10123
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NDUFA10 Antibody |
| Antibody SKU: | CAB10123 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-300 of human NDUFA10 (NP_004535.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:4000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, HL-60, BT-474, Jurkat, Mouse liver, Mouse kidney, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-300 of human NDUFA10 (NP_004535.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LRYG MWHF LLGD KASK RLTE RSRV ITVD GNIC TGKG KLAK EIAE KLGF KHFP EAGI HYPD STTG DGKP LATD YNGN CSLE KFYD DPRS NDGN SYRL QSWL YSSR LLQY SDAL EHLL TTGQ GVVL ERSI FSDF VFLE AMYN QGFI RKQC VDHY NEVK SVTI CDYL PPHL VIYI DVPV PEVQ RRIQ KKGD PHEM KITS AYLQ DIEN AYKK TFLP EMSE KCEV LQYS AREA QDSK KVVE DIEY LKFD KGPW LKQD NRTL YHLR LLVQ D |
| Gene ID: | 4705 |
| Uniprot: | O95299 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 40kDa/48kDa |
| Observed MW: | 38-42kDa |
| Synonyms: | NDUFA10, CI-42KD, CI-42k |
| Background: | The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. |
| UniProt Protein Function: | NDUFA10: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFA10 subunit family. |
| UniProt Protein Details: | Protein type:EC 1.6.5.3; EC 1.6.99.3; Oxidoreductase; Energy Metabolism - oxidative phosphorylation; Mitochondrial Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex I Biological Process: mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly Disease: Leigh Syndrome |
| NCBI Summary: | The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. [provided by RefSeq, Apr 2016] |
| UniProt Code: | O95299 |
| NCBI GenInfo Identifier: | 6093592 |
| NCBI Gene ID: | 4705 |
| NCBI Accession: | O95299.1 |
| UniProt Secondary Accession: | O95299,Q8WXC9, |
| UniProt Related Accession: | O95299 |
| Molecular Weight: | 48,563 Da |
| NCBI Full Name: | NADH dehydrogenase |
| NCBI Synonym Full Names: | NADH:ubiquinone oxidoreductase subunit A10 |
| NCBI Official Symbol: | NDUFA10 |
| NCBI Official Synonym Symbols: | CI-42k; CI-42KD |
| NCBI Protein Information: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial |
| UniProt Protein Name: | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial |
| UniProt Synonym Protein Names: | Complex I-42kD; CI-42kD; NADH-ubiquinone oxidoreductase 42 kDa subunit |
| Protein Family: | NADH dehydrogenase |
| UniProt Gene Name: | NDUFA10 |
| UniProt Entry Name: | NDUAA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NDUFA10 antibody (CAB10123) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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