Anti-NDRG2 Antibody (CAB5319)
- SKU:
- CAB5319
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NDRG2 Antibody |
| Antibody SKU: | CAB5319 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 138-357 of human NDRG2 (NP_963832.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SK-Hep1, K-562, Lovo, Mouse liver, Mouse heart, Mouse brain, Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 138-357 of human NDRG2 (NP_963832.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LARY ALNH PDTV EGLV LINI DPNA KGWM DWAA HKLT GLTS SIPE MILG HLFS QEEL SGNS ELIQ KYRN IITH APNL DNIE LYWN SYNN RRDL NFER GGDI TLRC PVML VVGD QAPH EDAV VECN SKLD PTQT SFLK MADS GGQP QLTQ PGKL TEAF KYFL QGMG YMAS SCMT RLSR SRTA SLTS AASV DGNR SRSR TLSQ SSES GTLS SGPP GHTM EVSC |
| Gene ID: | 57447 |
| Uniprot: | Q9UN36 |
| Cellular Location: | Cell projection, Cytoplasm, growth cone, perinuclear region |
| Calculated MW: | 36kDa/37kDa/39kDa/40kDa |
| Observed MW: | 36kDa/41kDa |
| Synonyms: | NDRG2, SYLD |
| Background: | This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. |
| UniProt Protein Function: | NDRG2: a pro-apoptotic protein that may be involved in dendritic cell and neuron differentiation. May have anti-tumor activity. Generally not expressed in tumor cell lines. Unlike Ndr1, Ndr2 and Ndr3 appear not to be controlled by N-myc or c-myc. The loss of NDRG2 expression has been shown to be a prognostic indicator in gastric carcinomas. Five isoforms of the human protein are produced by alternative splicing. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease |
| UniProt Protein Details: | Protein type:Tumor suppressor; Apoptosis Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: nucleoplasm; Golgi apparatus; centrosome; growth cone; perinuclear region of cytoplasm; cytoplasm; microtubule organizing center; cytosol Molecular Function:protein binding Biological Process: Wnt receptor signaling pathway; substantia nigra development; negative regulation of smooth muscle cell proliferation; negative regulation of cytokine production; cell differentiation |
| NCBI Summary: | This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UN36 |
| NCBI GenInfo Identifier: | 20141615 |
| NCBI Gene ID: | 57447 |
| NCBI Accession: | Q9UN36.2 |
| UniProt Secondary Accession: | Q9UN36,Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, B3KUE3 B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, |
| UniProt Related Accession: | Q9UN36 |
| Molecular Weight: | 371 |
| NCBI Full Name: | Protein NDRG2 |
| NCBI Synonym Full Names: | NDRG family member 2 |
| NCBI Official Symbol: | NDRG2 |
| NCBI Official Synonym Symbols: | SYLD |
| NCBI Protein Information: | protein NDRG2; syld709613 protein; cytoplasmic protein Ndr1; NDR1-related protein NDR2; N-myc downstream regulator 2; N-myc downstream-regulated gene 2 protein |
| UniProt Protein Name: | Protein NDRG2 |
| UniProt Synonym Protein Names: | N-myc downstream-regulated gene 2 protein; Protein Syld709613 |
| Protein Family: | Protein |
| UniProt Gene Name: | NDRG2 |
| UniProt Entry Name: | NDRG2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NDRG2 antibody (CAB5319) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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