Anti-NCR1 Antibody (CAB14499)
- SKU:
- CAB14499
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-NCR1 Antibody |
| Antibody SKU: | CAB14499 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 151-303 of human NCR1 (NP_001138929.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Mouse spleen, Rat spleen, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 151-303 of human NCR1 (NP_001138929.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SMFL LLKE GRSS HVQR GYGK VQAE FPLG PVTT AHRG TYRC FGSY NNHA WSFP SEPV KLLV TGDI ENTS LAPE DPTF PDTW GTYL LTTE TGLQ KDHA LWDH TAQN LLRM GLAF LVLV ALVW FLVE DWLS RKRT RERA SRAS TWEG RRRL NTQT L |
| Gene ID: | 9437 |
| Uniprot: | O76036 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 21kDa/22kDa/23kDa/32kDa/34kDa |
| Observed MW: | 46kDa |
| Synonyms: | CD335, LY94, NK-p46, NKP46, NCR1 |
| Background: |
| UniProt Protein Function: | NCR1: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Apoptosis Chromosomal Location of Human Ortholog: 19q13.42 Cellular Component: SWI/SNF complex; integral to plasma membrane Molecular Function:receptor signaling protein activity Biological Process: regulation of natural killer cell mediated cytotoxicity; natural killer cell activation; cellular defense response; signal transduction |
| UniProt Code: | O76036 |
| NCBI GenInfo Identifier: | 47605775 |
| NCBI Gene ID: | 9437 |
| NCBI Accession: | O76036.1 |
| UniProt Secondary Accession: | O76036,O76016, O76017, O76018, B0V3L2, B0V3L3, B0V3L4 B0V3L5, B8JL03, |
| UniProt Related Accession: | O76036 |
| Molecular Weight: | 34,409 Da |
| NCBI Full Name: | Natural cytotoxicity triggering receptor 1 |
| NCBI Synonym Full Names: | natural cytotoxicity triggering receptor 1 |
| NCBI Official Symbol: | NCR1 |
| NCBI Official Synonym Symbols: | LY94; CD335; NKP46; NK-p46 |
| NCBI Protein Information: | natural cytotoxicity triggering receptor 1; NK cell-activating receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); natural killer cell p46-related protein |
| UniProt Protein Name: | Natural cytotoxicity triggering receptor 1 |
| UniProt Synonym Protein Names: | Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD_antigen: CD335 |
| Protein Family: | Niemann-Pick type C-related protein |
| UniProt Gene Name: | NCR1 |
| UniProt Entry Name: | NCTR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NCR1 antibody (CAB14499) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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