Anti-NCF1 Antibody (CAB5143)
- SKU:
- CAB5143
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-NCF1 Antibody |
| Antibody SKU: | CAB5143 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human NCF1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | Raji |
| Immunogen: | A synthesized peptide derived from human NCF1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 653361 |
| Uniprot: | P14598 |
| Cellular Location: | |
| Calculated MW: | 45kDa |
| Observed MW: | 47KDa |
| Synonyms: | NCF1A, NOXO2, SH3PXD1A, p47phox |
| Background: | The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | p47phox: the 47-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. The holo-oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Contains 2 SH2 domains. Mutations in NCF1, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.-.-.- Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: cytosol; extrinsic to membrane; NADPH oxidase complex Molecular Function:electron carrier activity; phosphatidylinositol-3,4-bisphosphate binding; phosphoinositide binding; protein binding; SH3 domain binding; superoxide-generating NADPH oxidase activity Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; cell proliferation; cell redox homeostasis; cellular defense response; hydrogen peroxide biosynthetic process; inflammatory response; innate immune response; leukotriene metabolic process; negative regulation of smooth muscle contraction; protein targeting to membrane; respiratory burst; respiratory burst during defense response; response to yeast; small GTPase mediated signal transduction; superoxide metabolic process; superoxide release; vascular endothelial growth factor receptor signaling pathway Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type I |
| NCBI Summary: | The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P14598 |
| NCBI GenInfo Identifier: | 325511390 |
| NCBI Gene ID: | 653361 |
| NCBI Accession: | P14598.3 |
| UniProt Secondary Accession: | P14598,O43842, Q2PP07, Q53FR5, Q9BU90, Q9BXI7, Q9BXI8 Q9UDV9, Q9UMU2, A6NEH2, A8K7S9, |
| UniProt Related Accession: | P14598 |
| Molecular Weight: | |
| NCBI Full Name: | Neutrophil cytosol factor 1 |
| NCBI Synonym Full Names: | neutrophil cytosolic factor 1 |
| NCBI Official Symbol: | NCF1 |
| NCBI Official Synonym Symbols: | NCF1A; NOXO2; p47phox; SH3PXD1A |
| NCBI Protein Information: | neutrophil cytosol factor 1 |
| UniProt Protein Name: | Neutrophil cytosol factor 1 |
| UniProt Synonym Protein Names: | 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox |
| Protein Family: | Neutrophil cytosol factor |
| UniProt Gene Name: | NCF1 |
| UniProt Entry Name: | NCF1_HUMAN |
 | Western blot - NCF1 Rabbit mAb (CAB5143) |
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