Anti-NCAM1 Antibody,PE Conjugated (MACO0306)
- SKU:
- MACO0306
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Application:
- ELISA
- Application:
- IF
- Application:
- FC
- Antibody type:
- Monoclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Product Name: | Anti-NCAM1 Antibody,PE Conjugated |
| Product Sku: | MACO0306 |
| Size: | 100ul |
| Host Species: | Mouse |
| Tested Applications: | ELISA, IF, FC |
| Recommended Dilutions: | IF:1:100-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Protein |
| Form: | Liquid |
| Storage Buffer: | Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA |
| Purification Method: | Affinity purified |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Conjugate: | Non-conjugated |
| Background: | COC56 reacts with CD56, a 175-220 kDa Neural Cell Adhesion Molecule (NCAM), expressed on 10-25% of peripheral blood lymphocytes, including all CD16+ NK cells and approximately 5% of CD3+ lymphocytes, referred to as NKT cells. It also is present at brain and neuromuscular junctions, certain LGL leukemias, small cell lung carcinomas, neuronally derived tumors, myeloma and myeloid leukemias. CD56 (NCAM) is involved in neuronal homotypic cell adhesion which is implicated in neural development, and in cell differentiation during embryogenesis.1. Knapp, W et al., eds. (1989) Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York.2. Lanier LL . et al. (1991) J. Immunol. 146:4421-4426.3. Campbell, JJ et al. (2001) J. Immunol . 166:6477-6482.4. Cooper MD et al. (2001) Trends in Immunol. 22:633-640.5. Galandrini R et al. (2002) Blood. 100:4581-4589. |
| Synonyms: |
| UniProt Protein Function: | NCAM1: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q23.1 Cellular Component: Golgi membrane; cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane Molecular Function:identical protein binding Biological Process: axon guidance; extracellular matrix organization and biogenesis; cytokine and chemokine mediated signaling pathway; cell adhesion |
| NCBI Summary: | This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011] |
| UniProt Code: | P13591 |
| NCBI GenInfo Identifier: | 205830665 |
| NCBI Gene ID: | 4684 |
| NCBI Accession: | P13591.3 |
| UniProt Related Accession: | P13591 |
| Molecular Weight: | |
| NCBI Full Name: | Neural cell adhesion molecule 1 |
| NCBI Synonym Full Names: | neural cell adhesion molecule 1 |
| NCBI Official Symbol: | NCAM1 |
| NCBI Official Synonym Symbols: | CD56; NCAM; MSK39 |
| NCBI Protein Information: | neural cell adhesion molecule 1 |
| UniProt Protein Name: | Neural cell adhesion molecule 1 |
| UniProt Synonym Protein Names: | CD_antigen: CD56 |
| UniProt Gene Name: | NCAM1 |
| UniProt Entry Name: | NCAM1_HUMAN |
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