Anti-NAPSA Antibody (CAB5594)
- SKU:
- CAB5594
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Antibody Name: | Anti-NAPSA Antibody |
Antibody SKU: | CAB5594 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-250 of human NAPSA (NP_004842.1). |
Application: | WB IF |
Recommended Dilution: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | 293T |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-250 of human NAPSA (NP_004842.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | TLIR IPLH RVQP GRRI LNLL RGWR EPAE LPKL GAPS PGDK PIFV PLSN YRDV QYFG EIGL GTPP QNFT VAFD TGSS NLWV PSRR CHFF SVPC WLHH RFDP KASS SFQA NGTK FAIQ YGTG RVDG ILSE DKLT IGGI KGAS VIFG EALW EPSL VFAF AHFD GILG LGFP ILSV EGVR PPMD VLVE QGLL DKPV FSFY LNRD PEEP DGGE LVLG GSDP AHYI PPLT FV |
Gene ID: | 9476 |
Uniprot: | O96009 |
Cellular Location: | Secreted |
Calculated MW: | 45kDa |
Observed MW: | 45kDa |
Synonyms: | NAPSA, KAP, Kdap, NAP1, NAPA, SNAPA, napsin-A, Napsin A |
Background: | This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. |
UniProt Protein Function: | NAPSA: May be involved in processing of pneumocyte surfactant precursors. Belongs to the peptidase A1 family. |
UniProt Protein Details: | Protein type:EC 3.4.23.-; Protease; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: extracellular space; lysosome Molecular Function:aspartic-type endopeptidase activity; endopeptidase activity; peptidase activity Biological Process: cellular protein metabolic process; membrane protein proteolysis; protein catabolic process; surfactant homeostasis |
NCBI Summary: | This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016] |
UniProt Code: | O96009 |
NCBI GenInfo Identifier: | 6225749 |
NCBI Gene ID: | 9476 |
NCBI Accession: | O96009.1 |
UniProt Secondary Accession: | O96009,Q8WWD9, |
UniProt Related Accession: | O96009 |
Molecular Weight: | 45,387 Da |
NCBI Full Name: | Napsin-A |
NCBI Synonym Full Names: | napsin A aspartic peptidase |
NCBI Official Symbol: | NAPSA |
NCBI Official Synonym Symbols: | KAP; Kdap; NAP1; NAPA; SNAPA |
NCBI Protein Information: | napsin-A |
UniProt Protein Name: | Napsin-A |
UniProt Synonym Protein Names: | Aspartyl protease 4; ASP4; Asp 4; Napsin-1; TA01/TA02 |
Protein Family: | Napsin |
UniProt Gene Name: | NAPSA |