Anti-NAPRT Antibody (CAB11591)
- SKU:
- CAB11591
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-NAPRT Antibody |
| Antibody SKU: | CAB11591 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 309-538 of human NAPRT1 (NP_660202.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 309-538 of human NAPRT1 (NP_660202.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ELGY RAVG VRLD SGDL LQQA QEIR KVFR AAAA QFQV PWLE SVLI VVSN NIDE EALA RLAQ EGSE VNVI GIGT SVVT CPQQ PSLG GVYK LVAV GGQP RMKL TEDP EKQT LPGS KAAF RLLG SDGS PLMD MLQL AEEP VPQA GQEL RVWP PGAQ EPCT VRPA QVEP LLRL CLQQ GQLC EPLP SLAE SRAL AQLS LSRL SPEH RRLR SPAQ YQVV LSER LQAL VNSL CAGQ SP |
| Gene ID: | 93100 |
| Uniprot: | Q6XQN6 |
| Cellular Location: | Cytoplasm, cytosol |
| Calculated MW: | 56kDa/57kDa/60kDa |
| Observed MW: | 55kDa |
| Synonyms: | NAPRT, NAPRT1, PP3856 |
| Background: |
| UniProt Protein Function: | NAPRT1: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. Belongs to the NAPRTase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.4.21; Transferase Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: cytosol; extracellular region Molecular Function:nicotinate phosphoribosyltransferase activity; protein binding Biological Process: neutrophil degranulation; response to oxidative stress |
| NCBI Summary: | Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6XQN6 |
| NCBI GenInfo Identifier: | 166221824 |
| NCBI Gene ID: | 93100 |
| NCBI Accession: | Q6XQN6.2 |
| UniProt Secondary Accession: | Q6XQN6,Q6PJL1, Q6XQN4, Q6XQN5, Q8N5E8, Q9BRG0, A7BFI3 |
| UniProt Related Accession: | Q6XQN6 |
| Molecular Weight: | 58kDa |
| NCBI Full Name: | Nicotinate phosphoribosyltransferase |
| NCBI Synonym Full Names: | nicotinate phosphoribosyltransferase |
| NCBI Official Symbol: | NAPRT |
| NCBI Official Synonym Symbols: | NAPRT1; PP3856 |
| NCBI Protein Information: | nicotinate phosphoribosyltransferase |
| UniProt Protein Name: | Nicotinate phosphoribosyltransferase |
| UniProt Synonym Protein Names: | FHA-HIT-interacting protein; Nicotinate phosphoribosyltransferase domain-containing protein 1 |
| UniProt Gene Name: | NAPRT |
 | Western blot analysis of extracts of various cell lines, using NAPRT Antibody (CAB11591) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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