Anti-MZB1 Antibody (CAB14479)
- SKU:
- CAB14479
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-MZB1 Antibody |
| Antibody SKU: | CAB14479 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human MZB1 (NP_057543.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-189 of human MZB1 (NP_057543.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MRLS LPLL LLLL GAWA IPGG LGDR APLT ATAP QLDD EEMY SAHM PAHL RCDA CRAV AYQM WQNL AKAE TKLH TSNS GGRR ELSE LVYT DVLD RSCS RNWQ DYGV REVD QVKR LTGP GLSE GPEP SISV MVTG GPWP TRLS RTCL HYLG EFGE DQIY EAHQ QGRG ALEA LLCG GPQG ACSE KVSA TREE L |
| Gene ID: | 51237 |
| Uniprot: | Q8WU39 |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum lumen, Secreted |
| Calculated MW: | 6kDa/8kDa/10kDa/13kDa/20kDa |
| Observed MW: | 21kDa |
| Synonyms: | MZB1, MEDA-7, PACAP, pERp1 |
| Background: |
| UniProt Protein Function: | MEDA-7: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Belongs to the PERP1 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Cytokine Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: endoplasmic reticulum lumen; cytoplasm; extracellular region Molecular Function:protein binding Biological Process: integrin activation; apoptosis; positive regulation of cell proliferation; regulation of B cell proliferation; positive regulation of immunoglobulin biosynthetic process; regulation of cell proliferation |
| UniProt Code: | Q8WU39 |
| NCBI GenInfo Identifier: | 117938314 |
| NCBI Gene ID: | 51237 |
| NCBI Accession: | NP_057543.2 |
| UniProt Secondary Accession: | Q8WU39,Q7Z6N2, Q96RL5, Q9P0T3, D2IYS0, |
| UniProt Related Accession: | Q8WU39 |
| Molecular Weight: | 6,681 Da |
| NCBI Full Name: | marginal zone B- and B1-cell-specific protein |
| NCBI Synonym Full Names: | marginal zone B and B1 cell-specific protein |
| NCBI Official Symbol: | MZB1 |
| NCBI Official Synonym Symbols: | PACAP; pERp1; MEDA-7 |
| NCBI Protein Information: | marginal zone B- and B1-cell-specific protein; HSPC190; caspase-2 binding protein; mesenteric estrogen-dependent adipose 7; mesenteric oestrogen-dependent adipose gene- 7; plasma cell-induced ER protein 1; plasma cell-induced resident ER protein; plasma cell-induced resident endoplasmic reticulum protein; proapoptotic caspase adapter protein; proapoptotic caspase adaptor protein |
| UniProt Protein Name: | Marginal zone B- and B1-cell-specific protein |
| UniProt Synonym Protein Names: | Mesenteric estrogen-dependent adipose 7; MEDA-7; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; pERp1; Proapoptotic caspase adapter protein |
| Protein Family: | Marginal zone B- and B1-cell-specific protein |
| UniProt Gene Name: | MZB1 |
| UniProt Entry Name: | MZB1_HUMAN |
 | Western blot analysis of extracts of Raji cells, using MZB1 antibody (CAB14479) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat heart using MZB1 antibody (CAB14479) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using MZB1 antibody (CAB14479) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using MZB1 antibody (CAB14479) at dilution of 1:100 (40x lens). |
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