Anti-MYST1 Antibody (CAB2208)
- SKU:
- CAB2208
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-MYST1 Antibody |
| Antibody SKU: | CAB2208 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human MYST1 (NP_892003.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | OVCAR3, NIH/3T3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human MYST1 (NP_892003.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAQ GAAA AVAA GTSG VAGE GEPG PGEN AAAE GTAP SPGR VSPP TPAR GEPE VTVE IGET YLCR RPDS TWHS AEVI QSRV NDQE GREE FYVH YVGF NRRL DEWV DKNR LALT KTVK DAVQ KNSE KYLS ELAE QPER KITR NQKR KHDE INHV QKTY AEMD PTTA ALEK EHEA ITKV KYVD KIHI GNYE IDAW YFSP FPED |
| Gene ID: | 84148 |
| Uniprot: | Q9H7Z6 |
| Cellular Location: | Chromosome, Nucleus |
| Calculated MW: | 52kDa/53kDa |
| Observed MW: | 58kDa |
| Synonyms: | KAT8, MOF, MYST1, ZC2HC8, hMOF |
| Background: | This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MYST1: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Belongs to the MYST (SAS/MOZ) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.3.1.48; Acetyltransferase Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: kinetochore; nucleoplasm; nuclear membrane; nucleus; histone acetyltransferase complex Molecular Function:protein binding; histone acetyltransferase activity; enzyme binding; metal ion binding; acetyltransferase activity; histone acetyltransferase activity (H4-K16 specific); transcription factor binding; methylated histone residue binding Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; myeloid cell differentiation; regulation of autophagy; histone acetylation; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9H7Z6 |
| NCBI GenInfo Identifier: | 68565938 |
| NCBI Gene ID: | 84148 |
| NCBI Accession: | Q9H7Z6.2 |
| UniProt Related Accession: | Q9H7Z6 |
| Molecular Weight: | |
| NCBI Full Name: | Histone acetyltransferase KAT8 |
| NCBI Synonym Full Names: | lysine acetyltransferase 8 |
| NCBI Official Symbol: | KAT8 |
| NCBI Official Synonym Symbols: | MOF; hMOF; MYST1; ZC2HC8 |
| NCBI Protein Information: | histone acetyltransferase KAT8 |
| UniProt Protein Name: | Histone acetyltransferase KAT8 |
| UniProt Synonym Protein Names: | Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; hMOF |
| Protein Family: | Males-absent on the first protein |
| UniProt Gene Name: | KAT8 |
| UniProt Entry Name: | KAT8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using KAT8 antibody (CAB2208) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunofluorescence analysis of U-2 OS cells using MYST1 Polyclonal Antibody (CAB2208) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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