Anti-MYRF Antibody (CAB16355)

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SKU:
CAB16355
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology
Frequently bought together:

Description

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Antibody Name:Anti-MYRF Antibody
Antibody SKU:CAB16355
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MYRF (NP_001120864.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, HepG2
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MYRF (NP_001120864.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEVV DETE ALQR FFEG HDIN GALE PSNI DTSI LEEY ISKE DASD LCFP DISA PASS ASYS HGQP AMPG SSGV HHLS PPGG GPSP GRHG PLPP PGYG TPLN
Gene ID:745
Uniprot:Q9Y2G1
Cellular Location:Cytoplasm, Endoplasmic reticulum membrane, Nucleus, Single-pass membrane protein
Calculated MW:120kDa/124kDa
Observed MW:124kDa
Synonyms:MYRF, C11orf9, MRF, Ndt80, pqn-47
Background:This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832).
NCBI Summary:This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
UniProt Code:Q9Y2G1
NCBI GenInfo Identifier:188528652
NCBI Gene ID:745
NCBI Accession:NP_001120864.1
UniProt Secondary Accession:Q9Y2G1,O43582, Q9P1Q6,
UniProt Related Accession:Q9Y2G1
Molecular Weight:120,225 Da
NCBI Full Name:myelin regulatory factor isoform 2
NCBI Synonym Full Names:myelin regulatory factor
NCBI Official Symbol:MYRF  
NCBI Official Synonym Symbols:MRF; Ndt80; pqn-47; C11orf9  
NCBI Protein Information:myelin regulatory factor
UniProt Protein Name:Myelin regulatory factor
UniProt Synonym Protein Names:Myelin gene regulatory factor
UniProt Gene Name:MYRF  
Anti-MYRF Antibody (CAB16355)Western blot analysis of extracts of various cell lines, using MYRF Rabbit pAb (CAB16355) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

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