Anti-MYLK3 Antibody (CAB6663)
- SKU:
- CAB6663
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MYLK3 Antibody |
| Antibody SKU: | CAB6663 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MYLK3 (NP_872299.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MYLK3 (NP_872299.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSGT SKES LGHG GLPG LGKT CLTT MDTK LNML NEKV DQLL HFQE DVTE KLQS MCRD MGHL ERGL HRLE ASRA PGPG GADG VPHI DTQA GWPE VLEL VRAM QQDA AQHG ARLE ALFR MVAA VDRA IALV GATF QKSK VADF LMQG RVPW RRGS PGDS PEEN KERV EEEG GKPK HVLS TSGV QSDA REPG EESQ KADV LEGT AERL PPIR ASGL GADP AQAV VSPG QGDG VPGP AQAF PGHL |
| Gene ID: | 91807 |
| Uniprot: | Q32MK0 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 52kDa/88kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | MYLK3, MLCK, MLCK2, caMLCK |
| Background: |
| UniProt Protein Function: | caMLCK: Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:CAMK group; EC 2.7.11.18; Kinase, protein; MLCK family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 16q11.2 Cellular Component: actin cytoskeleton; cytoplasm; cytosol; intracellular Molecular Function:ATP binding; calmodulin-dependent protein kinase activity; myosin light chain kinase activity Biological Process: cardiac myofibril assembly; cellular response to interleukin-1; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid phosphorylation; regulation of vascular permeability during acute inflammatory response; sarcomere organization; sarcomerogenesis |
| NCBI Summary: | Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008] |
| UniProt Code: | Q32MK0 |
| NCBI GenInfo Identifier: | 815930021 |
| NCBI Gene ID: | 91807 |
| NCBI Accession: | NP_001295230.1 |
| UniProt Secondary Accession: | Q32MK0,Q96DV1, |
| UniProt Related Accession: | Q32MK0 |
| Molecular Weight: | 52,723 Da |
| NCBI Full Name: | myosin light chain kinase 3 isoform 2 |
| NCBI Synonym Full Names: | myosin light chain kinase 3 |
| NCBI Official Symbol: | MYLK3 |
| NCBI Official Synonym Symbols: | MLCK; MLCK2; caMLCK |
| NCBI Protein Information: | myosin light chain kinase 3 |
| UniProt Protein Name: | Myosin light chain kinase 3 |
| UniProt Synonym Protein Names: | Cardiac-MyBP-C-associated Ca/CaM kinase; Cardiac-MLCK |
| Protein Family: | Myosin light chain kinase |
| UniProt Gene Name: | MYLK3 |
 | Immunofluorescence analysis of U2OS cells using MYLK3 antibody (CAB6663). Blue: DAPI for nuclear staining. |
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