Anti-MYBPC3 항체 (CAB12351)

Antibody Name:	Anti-MYBPC3 Antibody
Antibody SKU:	CAB12351
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human MYBPC3 (NP_000247.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Mouse, Rat
Positive Samples:	Rat heart

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human MYBPC3 (NP_000247.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	SSKV GQHL QLHD SYDR ASKV YLFE LHIT DAQP AFTG SYRC EVST KDKF DCSN FNLT VHEA MGTG DLDL LSAF RRTS LAGG GRRI SDSH EDTG ILDF SSLL KKRD SFRT PRDS KLEA PAEE DVWE ILRQ APPS EYER IAFQ YGVT DLRG MLKR LKGM RRDE KKST AFQK KLEP AYQV SKGH KIRL TVEL ADHD AEVK WLKN G
Gene ID:	4607
Uniprot:	Q14896
Cellular Location:
Calculated MW:	140kDa
Observed MW:	170kDa

Synonyms:

MYBPC3, CMD1MM, CMH4, FHC, LVNC10, MYBP-C, cardiac

Background:

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

UniProt Protein Function:	MYBPC3: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family.
UniProt Protein Details:	Protein type:Myosin-binding Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: A band; cytosol; sarcomere; striated muscle thick filament Molecular Function:ATPase activator activity; identical protein binding; myosin binding; myosin heavy chain binding; protein binding; structural constituent of muscle Biological Process: cardiac muscle contraction; heart morphogenesis; muscle filament sliding; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis Disease: Cardiomyopathy, Familial Hypertrophic, 4; Left Ventricular Noncompaction 10
NCBI Summary:	MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Code:	Q14896
NCBI GenInfo Identifier:	425906074
NCBI Gene ID:	4607
NCBI Accession:	Q14896.4
UniProt Secondary Accession:	Q14896,Q16410, Q6R2F7, Q9UE27, Q9UM53, A5PL00,
UniProt Related Accession:	Q14896
Molecular Weight:	140,703 Da
NCBI Full Name:	Myosin-binding protein C, cardiac-type
NCBI Synonym Full Names:	myosin binding protein C, cardiac
NCBI Official Symbol:	MYBPC3
NCBI Official Synonym Symbols:	FHC; CMH4; CMD1MM; LVNC10; MYBP-C
NCBI Protein Information:	myosin-binding protein C, cardiac-type
UniProt Protein Name:	Myosin-binding protein C, cardiac-type
UniProt Synonym Protein Names:	C-protein, cardiac muscle isoform
Protein Family:	Myosin-binding protein
UniProt Gene Name:	MYBPC3
UniProt Entry Name:	MYPC3_HUMAN

	Western blot analysis of extracts of rat heart, using MYBPC3 antibody (CAB12351) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
	Immunohistochemistry of paraffin-embedded rat heart using MYBPC3 antibody (CAB12351) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse heart using MYBPC3 antibody (CAB12351) at dilution of 1:100 (40x lens).

Antibodies	ELISA Kits
MYBPC3 Antibody (PACO05980)	Human MyBPC3 / Myosin Binding Protein C, Cardiac ELISA Kit
MYBPC3 Antibody (PACO10671)	Human MYBPC3 (Myosin Binding Protein C, Cardiac) CLIA Kit (HUES00455)
	Human MYBPC3 (Myosin Binding Protein C, Cardiac) ELISA Kit (HUES01868)
	Human Myosin-binding protein C, cardiac-type (MYBPC3) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)