Anti-MVD Antibody (CAB15240)
- SKU:
- CAB15240
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-MVD Antibody |
| Antibody SKU: | CAB15240 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human MVD (NP_002452.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, A-549, LO2, BxPC-3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human MVD (NP_002452.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASE KPLA AVTC TAPV NIAV IKYW GKRD EELV LPIN SSLS VTLH QDQL KTTT TAVI SKDF TEDR IWLN GREE DVGQ PRLQ ACLR EIRC LARK RRNS RDGD PLPS SLSC KVHV ASVN NFPT AAGL ASSA AGYA CLAY TLAR VYGV ESDL SEVA RRGS GSAC RSLY GGFV EWQM GEQA DGKD SIAR QVAP ESHW PELR VLIL VVSA EKKL TGST VGMR ASVE TSPL LRFR AESV VPAR MAEM ARCI RERD FPSF AQLT MKDS NQFH ATCL DT |
| Gene ID: | 4597 |
| Uniprot: | P53602 |
| Cellular Location: | |
| Calculated MW: | 43kDa |
| Observed MW: | 43kDa |
| Synonyms: | MVD, FP17780, MDDase, MPD, POROK7 |
| Background: | The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. |
| UniProt Protein Function: | MVD: Performs the first committed step in the biosynthesis of isoprenes. Belongs to the diphosphomevalonate decarboxylase family. |
| UniProt Protein Details: | Protein type:Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Lyase; EC 4.1.1.33 Chromosomal Location of Human Ortholog: 16q24.3 Cellular Component: cytosol; peroxisome Molecular Function:diphosphomevalonate decarboxylase activity; Hsp70 protein binding; protein homodimerization activity Biological Process: cholesterol biosynthetic process; dolichyl diphosphate biosynthetic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; positive regulation of cell proliferation |
| NCBI Summary: | The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P53602 |
| NCBI GenInfo Identifier: | 1706681 |
| NCBI Gene ID: | 4597 |
| NCBI Accession: | P53602.1 |
| UniProt Secondary Accession: | P53602,Q53Y65, |
| UniProt Related Accession: | P53602 |
| Molecular Weight: | 43,405 Da |
| NCBI Full Name: | Diphosphomevalonate decarboxylase |
| NCBI Synonym Full Names: | mevalonate diphosphate decarboxylase |
| NCBI Official Symbol: | MVD |
| NCBI Official Synonym Symbols: | MPD; MDDase; POROK7; FP17780 |
| NCBI Protein Information: | diphosphomevalonate decarboxylase |
| UniProt Protein Name: | Diphosphomevalonate decarboxylase |
| UniProt Synonym Protein Names: | Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase |
| UniProt Gene Name: | MVD |
| UniProt Entry Name: | MVD1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MVD antibody (CAB15240) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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