Anti-MVB12A Antibody (CAB15930)
- SKU:
- CAB15930
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MVB12A Antibody |
| Antibody SKU: | CAB15930 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human MVB12A (NP_612410.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human MVB12A (NP_612410.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDPV PGTD SAPL AGLA WSSA SAPP PRGF SAIS CTVE GAPA SFGK SFAQ KSGY FLCL SSLG SLEN PQEN VVAD IQIV VDKS PLPL GFSP VCDP MDSK ASVS KKKR MCVK LLPL GATD TAVF DVRL SGKT KTVP GYLR IGDM GGFA IWCK KAKA PRPV PKPR GLSR DMQG LSLD AASQ PSKG GLLE RTAS RLGS RAST LRRN DSIY EASS LYGI SAMD GVPF TLHP RFEG KSCS PLAF SAFG DLTI KSLA DIEE EYNY GFVV EKTA AARL PPSV S |
| Gene ID: | 93343 |
| Uniprot: | Q96EY5 |
| Cellular Location: | Cytoplasm, Endosome, Late endosome membrane, Nucleus, Peripheral membrane protein, centrosome, cytoskeleton, microtubule organizing center |
| Calculated MW: | 24kDa/27kDa/28kDa |
| Observed MW: | 29kDa |
| Synonyms: | MVB12A, CFBP, FAM125A |
| Background: |
| UniProt Protein Function: | FAM125A: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor. Belongs to the FAM125 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: centrosome; cytoplasm; cytosol; intracellular membrane-bound organelle; nucleoplasm; vesicle Molecular Function:lipid binding; protein binding; ubiquitin binding Biological Process: autophagy; positive regulation of viral reproduction; regulation of epidermal growth factor receptor signaling pathway; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; virus maturation |
| UniProt Code: | Q96EY5 |
| NCBI GenInfo Identifier: | 74731632 |
| NCBI Gene ID: | 93343 |
| NCBI Accession: | Q96EY5.1 |
| UniProt Secondary Accession: | Q96EY5,Q96I18, |
| UniProt Related Accession: | Q96EY5 |
| Molecular Weight: | 28783 Da |
| NCBI Full Name: | Multivesicular body subunit 12A |
| NCBI Synonym Full Names: | multivesicular body subunit 12A |
| NCBI Official Symbol: | MVB12A |
| NCBI Official Synonym Symbols: | CFBP; FAM125A |
| NCBI Protein Information: | multivesicular body subunit 12A |
| UniProt Protein Name: | Multivesicular body subunit 12A |
| UniProt Synonym Protein Names: | CIN85/CD2AP family-binding protein; ESCRT-I complex subunit MVB12A; Protein FAM125A |
| Protein Family: | Multivesicular body |
| UniProt Gene Name: | MVB12A |
| UniProt Entry Name: | MB12A_HUMAN |
 | Western blot analysis of extracts of mouse liver, using MVB12A antibody (CAB15930) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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