Anti-MUL1 Antibody (CAB13125)

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SKU:
CAB13125
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
Frequently bought together:

Description

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Antibody Name:Anti-MUL1 Antibody
Antibody SKU:CAB13125
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-352 of human MUL1 (NP_078820.2).
Application:WB IHC IF
Recommended Dilution:WB 1:1000 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:A-375, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-352 of human MUL1 (NP_078820.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MESG GRPS LCQF ILLG TTSV VTAA LYSV YRQK ARVS QELK GAKK VHLG EDLK SILS EAPG KCVP YAVI EGAV RSVK ETLN SQFV ENCK GVIQ RLTL QEHK MVWN RTTH LWND CSKI IHQR TNTV PFDL VPHE DGVD VAVR VLKP LDSV DLGL ETVY EKFH PSIQ SFTD VIGH YISG ERPK GIQE TEEM LKVG ATLT GVGE LVLD NNSV RLQP PKQG MQYY LSSQ DFDS LLQR QESS VRLW KVLA LVFG FATC ATLF FILR KQYL QRQE RLRL KQMQ EEFQ EHEA QLLS RAKP EDRE SLKS ACVV CLSS FKSC VFLE CGHV CSCT ECYR ALPE PKKC PICR QAIT RVIP LYNS
Gene ID:79594
Uniprot:Q969V5
Cellular Location:Mitochondrion outer membrane, Multi-pass membrane protein, Peroxisome
Calculated MW:39kDa
Observed MW:45kDa
Synonyms:C1orf166, GIDE, MAPL, MULAN, RNF218, MUL1
Background:
UniProt Protein Function:MULAN: Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
UniProt Protein Details:

Protein type:Apoptosis; EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: axon; cell soma; cytoplasm; integral to mitochondrial outer membrane; membrane; mitochondrion; nucleoplasm; peroxisome

Molecular Function:identical protein binding; protein binding; signal transducer activity; SUMO ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: activation of JNK activity; caspase activation; mitochondrial fission; mitochondrion localization; negative regulation of cell growth; negative regulation of defense response to virus by host; negative regulation of innate immune response; negative regulation of protein kinase B signaling cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein sumoylation; protein destabilization; protein stabilization; protein ubiquitination

UniProt Code:Q969V5
NCBI GenInfo Identifier:74760689
NCBI Gene ID:79594
NCBI Accession:Q969V5.1
UniProt Secondary Accession:Q969V5,Q7Z431, Q9H9B5, B5M497,
UniProt Related Accession:Q969V5
Molecular Weight:39,800 Da
NCBI Full Name:Mitochondrial ubiquitin ligase activator of NFKB 1
NCBI Synonym Full Names:mitochondrial E3 ubiquitin protein ligase 1
NCBI Official Symbol:MUL1  
NCBI Official Synonym Symbols:GIDE; MAPL; MULAN; RNF218; C1orf166  
NCBI Protein Information:mitochondrial ubiquitin ligase activator of NFKB 1
UniProt Protein Name:Mitochondrial ubiquitin ligase activator of NFKB 1
UniProt Synonym Protein Names:E3 SUMO-protein ligase MUL1; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; Mitochondrial-anchored protein ligase; MAPL; Putative NF-kappa-B-activating protein 266; RING finger protein 218; RING-type E3 ubiquitin transferase NFKB 1Curated
Protein Family:Mitochondrial ubiquitin ligase activator
UniProt Gene Name:MUL1  
Anti-MUL1 Antibody (CAB13125)Western blot analysis of extracts of various cell lines, using MUL1 antibody (CAB13125) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-MUL1 Antibody (CAB13125)Immunohistochemistry of paraffin-embedded human tonsil using MUL1 antibody (CAB13125) at dilution of 1:100 (40x lens).
Anti-MUL1 Antibody (CAB13125)Immunohistochemistry of paraffin-embedded human liver cancer using MUL1 antibody (CAB13125) at dilution of 1:100 (40x lens).
Anti-MUL1 Antibody (CAB13125)Immunofluorescence analysis of RAW264.7 cells using MUL1 antibody (CAB13125) at dilution of 1:100. Blue: DAPI for nuclear staining.
Anti-MUL1 Antibody (CAB13125)Immunofluorescence analysis of THP-1 cells using MUL1 antibody (CAB13125) at dilution of 1:100. Blue: DAPI for nuclear staining.

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