Anti-MTMR2 Antibody (CAB8993)
- SKU:
- CAB8993
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-MTMR2 Antibody |
| Antibody SKU: | CAB8993 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 404-643 of human MTMR2 (NP_057240.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, U-87MG, Mouse brain, Mouse kidney, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 404-643 of human MTMR2 (NP_057240.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DKVE SGKT SVVV HCSD GWDR TAQL TSLA MLML DGYY RTIR GFEV LVEK EWLS FGHR FQLR VGHG DKNH ADAD RSPV FLQF IDCV WQMT RQFP TAFE FNEY FLIT ILDH LYSC LFGT FLCN SEQQ RGKE NLPK RTVS LWSY INSQ LEDF TNPL YGSY SNHV LYPV ASMR HLEL WVGY YIRW NPRM KPQE PIHN RYKE LLAK RAEL QKKV EELQ REIS NRST SSSE RASS PAQC VTPV QTVV |
| Gene ID: | 8898 |
| Uniprot: | Q13614 |
| Cellular Location: | Cytoplasm, Early endosome membrane, Peripheral membrane protein |
| Calculated MW: | 65kDa/73kDa |
| Observed MW: | 65-73kDa |
| Synonyms: | MTMR2, CMT4B, CMT4B1 |
| Background: | This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3, 5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. |
| UniProt Protein Function: | MTMR2: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. Homooligomer and heterooligomer. Interacts with SBF1 and SBF2. interaction with SBF1 increases phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. |
| UniProt Protein Details: | Protein type:EC 3.1.3.95; Protein phosphatase, tyrosine (non-receptor); Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.64; Phosphatase, lipid; Motility/polarity/chemotaxis; Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - thiamine Chromosomal Location of Human Ortholog: 11q22 Cellular Component: synaptic vesicle; early endosome membrane; axon; vacuolar membrane; dendrite; cytoplasm; dendritic spine; nucleus; cytosol Molecular Function:protein binding; phosphatidylinositol-3-phosphatase activity; protein homodimerization activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity Biological Process: myelin formation; negative regulation of myelination; inositol phosphate dephosphorylation; negative regulation of endocytosis; phospholipid metabolic process; phosphatidylinositol biosynthetic process; neuron development; phosphoinositide dephosphorylation; protein amino acid dephosphorylation; protein tetramerization; negative regulation of receptor internalization Disease: Charcot-marie-tooth Disease, Type 4b1 |
| NCBI Summary: | This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q13614 |
| NCBI GenInfo Identifier: | 343790884 |
| NCBI Gene ID: | 8898 |
| NCBI Accession: | NP_001230500.1 |
| UniProt Secondary Accession: | Q13614,Q9UPS9, A6NN98, |
| UniProt Related Accession: | Q13614 |
| Molecular Weight: | 73,381 Da |
| NCBI Full Name: | myotubularin-related protein 2 isoform 2 |
| NCBI Synonym Full Names: | myotubularin related protein 2 |
| NCBI Official Symbol: | MTMR2 |
| NCBI Official Synonym Symbols: | CMT4B; CMT4B1 |
| NCBI Protein Information: | myotubularin-related protein 2 |
| UniProt Protein Name: | Myotubularin-related protein 2 |
| Protein Family: | Myotubularin-related protein |
| UniProt Gene Name: | MTMR2 |
| UniProt Entry Name: | MTMR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTMR2 antibody (CAB8993) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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