Anti-MTCH1 Antibody (CAB8063)

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SKU:
CAB8063
Product type:
Antibody
Application:
WB
Application:
IHC
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
Frequently bought together:

Description

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Antibody Name:MTCH1 Rabbit Polyclonal Antibody
Antibody SKU:CAB8063
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 100-250 of human MTCH1 (NP_001258570.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:MCF7, HepG2, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 100-250 of human MTCH1 (NP_001258570.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LYVK LLIQ VGHE PMPP TLGT NVLG RKVL YLPS FFTY AKYI VQVD GKIG LFRG LSPR LMSN ALST VTRG SMKK VFPP DEIE QVSN KDDM KTSL KKVV KETS YEMM MQCV SRML AHPL HVIS MRCM VQFV GREA KYSG VLSS IGKI FKEE GLL
Gene ID:23787
Uniprot:Q9NZJ7
Cellular Location:Mitochondrion inner membrane, Multi-pass membrane protein
Calculated MW:19kDa/39kDa/41kDa
Observed MW:45-50kDa
Synonyms:MTCH1, CGI-64, PIG60, PSAP, SLC25A49
Background:This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
UniProt Protein Function:MTCH1: Potential mitochondrial transporter. May play a role in apoptosis. Belongs to the mitochondrial carrier family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial

Chromosomal Location of Human Ortholog: 6p21.2

Cellular Component: membrane; mitochondrion

Molecular Function:protein binding

Biological Process: caspase activation; positive regulation of apoptosis

NCBI Summary:This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]
UniProt Code:Q9NZJ7
NCBI GenInfo Identifier:74753085
NCBI Gene ID:23787
NCBI Accession:Q9NZJ7.1
UniProt Secondary Accession:Q9NZJ7,Q6PK60, Q6UX45, Q7L465, Q9BW23, Q9NZR6, Q9UJZ5 A8KAX5, B2RCE3,
UniProt Related Accession:Q9NZJ7
Molecular Weight:19,058 Da
NCBI Full Name:Mitochondrial carrier homolog 1
NCBI Synonym Full Names:mitochondrial carrier 1
NCBI Official Symbol:MTCH1  
NCBI Official Synonym Symbols:PSAP; PIG60; CGI-64; SLC25A49  
NCBI Protein Information:mitochondrial carrier homolog 1
UniProt Protein Name:Mitochondrial carrier homolog 1
UniProt Synonym Protein Names:Presenilin-associated protein
Protein Family:Mitochondrial carrier
UniProt Gene Name:MTCH1  
UniProt Entry Name:MTCH1_HUMAN
Anti-MTCH1 Polyclonal Antibody (CAB8063)Western blot analysis of extracts of various cell lines, using MTCH1 antibody (CAB8063) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
Anti-MTCH1 Polyclonal Antibody (CAB8063)Immunohistochemistry of paraffin-embedded human breast cancer using MTCH1 antibody (CAB8063) at dilution of 1:100 (40x lens).

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