| UniProt Protein Function: | MT-ND4: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND4 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND4 are a cause of Leber hereditary optic neuropathy with dystonia (LDYT); also called familial dystonia with visual failure and striatal lucencies. LDYT is part of a spectrum of Leber hereditary optic neuropathy. It is characterized by the association of optic atrophy and central vision loss with dystonia. Defects in MT-ND4 are a cause of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS). MELAS is a genetically heterogenious disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness. Belongs to the complex I subunit 4 family. |
| UniProt Protein Details: | Protein type:Energy Metabolism - oxidative phosphorylation; Mitochondrial; Membrane protein, multi-pass; EC 1.6.5.3; Membrane protein, integral; Oxidoreductase Chromosomal Location of Human Ortholog: - Disease: Leber Optic Atrophy |
| UniProt Code: | P03905 |
| NCBI GenInfo Identifier: | 251831116 |
| NCBI Gene ID: | 4538 |
| NCBI Accession: | YP_003024035.1 |
| UniProt Secondary Accession: | P03905,Q6RL39, Q6RQN9, Q8HNR8, |
| Molecular Weight: | |
| NCBI Full Name: | NADH dehydrogenase subunit 4 (mitochondrion) |
| NCBI Synonym Full Names: | mitochondrially encoded NADH dehydrogenase 4 |
| NCBI Official Symbol: | MT-ND4 |
| NCBI Official Synonym Symbols: | MTND4; ND4 |
| NCBI Protein Information: | NADH dehydrogenase, subunit 4 (complex I) |
| UniProt Protein Name: | NADH-ubiquinone oxidoreductase chain 4 |
| UniProt Synonym Protein Names: | NADH dehydrogenase subunit 4 |
| UniProt Gene Name: | MT-ND4 |
| UniProt Entry Name: | NU4M_HUMAN |
