Anti-MSLN Antibody (CAB14099)
- SKU:
- CAB14099
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MSLN Antibody |
| Antibody SKU: | CAB14099 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-296 of human MSLN (NP_001170826.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-296 of human MSLN (NP_001170826.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LAGE TGQE AAPL DGVL ANPP NISS LSPR QLLG FPCA EVSG LSTE RVRE LAVA LAQK NVKL STEQ LRCL AHRL SEPP EDLD ALPL DLLL FLNP DAFS GPQA CTRF FSRI TKAN VDLL PRGA PERQ RLLP AALA CWGV RGSL LSEA DVRA LGGL ACDL PGRF VAES AEVL LPRL VSCP GPLD QDQQ EAAR AALQ GGGP PYGP PSTW SVST MDAL RGLL PVLG QPII RSIP QGIV AAWR QRSS RDPS WRQP ERTI LRPR FRRE |
| Gene ID: | 10232 |
| Uniprot: | Q13421 |
| Cellular Location: | Cell membrane, GPI-anchor, Golgi apparatus, Lipid-anchor, Secreted |
| Calculated MW: | 67kDa/68kDa/71kDa |
| Observed MW: | Refer to figures |
| Synonyms: | MSLN, MPF, SMRP |
| Background: | This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
| UniProt Protein Function: | MSLN: Membrane-anchored forms may play a role in cellular adhesion. Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. Belongs to the mesothelin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Cell adhesion Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: Golgi apparatus; extracellular space; cell surface; membrane; plasma membrane Molecular Function:protein binding Biological Process: pancreas development; cell adhesion |
| NCBI Summary: | This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] |
| UniProt Code: | Q13421 |
| NCBI GenInfo Identifier: | 116242654 |
| NCBI Gene ID: | 10232 |
| NCBI Accession: | Q13421.2 |
| UniProt Secondary Accession: | Q13421,Q14859, Q4VQD5, Q96GR6, Q96KJ5, Q9BR17, Q9BTR2 Q9UCB2, Q9UK57, D3DU65, |
| UniProt Related Accession: | Q13421 |
| Molecular Weight: | 67,940 Da |
| NCBI Full Name: | Mesothelin |
| NCBI Synonym Full Names: | mesothelin |
| NCBI Official Symbol: | MSLN |
| NCBI Official Synonym Symbols: | MPF; SMRP |
| NCBI Protein Information: | mesothelin; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor |
| UniProt Protein Name: | Mesothelin |
| UniProt Synonym Protein Names: | CAK1 antigen; Pre-pro-megakaryocyte-potentiating factorCleaved into the following 2 chains:Megakaryocyte-potentiating factor; MPF; Mesothelin, cleaved form |
| Protein Family: | Mesothelin |
| UniProt Gene Name: | MSLN |
| UniProt Entry Name: | MSLN_HUMAN |
 | Immunohistochemistry of paraffin-embedded rat kidney using MSLN Antibody (CAB14099) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using MSLN antibody (CAB14099). Blue: DAPI for nuclear staining. |
Related Products
