| Background: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. |
| UniProt Protein Function: | MRPS31: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. |
| UniProt Protein Details: | Protein type:Mitochondrial; RNA-binding Chromosomal Location of Human Ortholog: 13q14.11 Cellular Component: mitochondrial inner membrane; mitochondrion; nucleolus Molecular Function:protein binding; protein domain specific binding |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92665 |
| NCBI GenInfo Identifier: | 93186129 |
| NCBI Gene ID: | 10240 |
| NCBI Accession: | Q92665.3 |
| UniProt Secondary Accession: | Q92665,Q5VYC8, Q8WTV8, B2RCS3, |
| UniProt Related Accession: | Q92665 |
| Molecular Weight: | 45,318 Da |
| NCBI Full Name: | 28S ribosomal protein S31, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein S31 |
| NCBI Official Symbol: | MRPS31 |
| NCBI Official Synonym Symbols: | S31mt; IMOGN38; MRP-S31 |
| NCBI Protein Information: | 28S ribosomal protein S31, mitochondrial |
| UniProt Protein Name: | 28S ribosomal protein S31, mitochondrial |
| UniProt Synonym Protein Names: | Imogen 38 |
| Protein Family: | 28S ribosomal protein |
| UniProt Gene Name: | MRPS31 |
| UniProt Entry Name: | RT31_HUMAN |
