Anti-MRP1/ABCC1 Antibody (CAB2223)

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SKU:
CAB2223
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ABC29
ABCC
GS-X
MRP
MRP1
Frequently bought together:

Description

Product Name:MRP1/ABCC1 Rabbit mAb
Product Code:CAB2223
Size:20uL, 50uL, 100uL
Synonyms:ABC29, ABCC, GS-X, MRP, MRP1
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human MRP1/ABCC1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549
Immunogen:A synthesized peptide derived from human MRP1/ABCC1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4363
Uniprot:P33527
Calculated MW:171kDa
Observed MW:150-250KDa
UniProt Protein Function:ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family; Transporter

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function:ATPase activity, coupled to transmembrane movement of substances; transporter activity; ATPase activity; ATP binding

Biological Process: response to drug; vitamin metabolic process; transport; cobalamin metabolic process; arachidonic acid metabolic process; leukotriene metabolic process; transmembrane transport; water-soluble vitamin metabolic process

NCBI Summary:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
UniProt Code:P33527
NCBI GenInfo Identifier:296439301
NCBI Gene ID:4363
NCBI Accession:P33527.3
UniProt Secondary Accession:P33527,O14819, O43333, P78419, Q59GI9, Q9UQ97, Q9UQ99 Q9UQA0, A3RJX2, C9JPJ4,
UniProt Related Accession:P33527
Molecular Weight:1531
NCBI Full Name:Multidrug resistance-associated protein 1
NCBI Synonym Full Names:ATP-binding cassette, sub-family C (CFTR/MRP), member 1
NCBI Official Symbol:ABCC1  
NCBI Official Synonym Symbols:MRP; ABCC; GS-X; MRP1; ABC29  
NCBI Protein Information:multidrug resistance-associated protein 1; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1de
UniProt Protein Name:Multidrug resistance-associated protein 1
UniProt Synonym Protein Names:ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter
Protein Family:37S ribosomal protein
UniProt Gene Name:ABCC1  
UniProt Entry Name:MRP1_HUMAN

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