Anti-MRI1 Antibody (CAB14344)
- SKU:
- CAB14344
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-MRI1 Antibody |
| Antibody SKU: | CAB14344 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human MRI1 (NP_001026897.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HepG2, HT-1080, Mouse heart, Mouse kidney, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human MRI1 (NP_001026897.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTLE AIRY SRGS LQIL DQLL LPKQ SRYE AVGS VHQA WEAI RAMK VRGA PAIA LVGC LSLA VELQ AGAG GPGL AALV AFVR DKLS FLVT ARPT AVNM ARAA RDLA DVAA REAE REGA TEEA VRER VICC TEDM LEKD LRDN RSIG DLGA RHLL ERVA PSGG KVTV LTHC NTGA LATA GYGT ALGV IRSL HSLG RLEH AFCT ETRP YNQG ARLT AFEL VYEQ IPAT LITD SMVA AAMA HRGV SAVV VGAD RVVA NGDT ANKV GTYQ LAIV AKHH GIPF YVAA PSSS CDLR LETG KEII IEER PGQE LTDV NGVR IAAP GIGV WNPA FDVT PHDL ITGG IITE LGVF APEE LRTA LTTT ISSR DGTL DGPQ M |
| Gene ID: | 84245 |
| Uniprot: | Q9BV20 |
| Cellular Location: | Cell projection, Cytoplasm, Nucleus |
| Calculated MW: | 34kDa/39kDa |
| Observed MW: | 45kDa |
| Synonyms: | MRI1, M1Pi, MRDI, MTNA, Ypr118w |
| Background: |
| UniProt Protein Function: | MRI1: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Isomerase; EC 5.3.1.23 Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: cytoplasm; cytosol; nucleolus Molecular Function:identical protein binding; S-methyl-5-thioribose-1-phosphate isomerase activity Biological Process: methionine salvage |
| NCBI Summary: | This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q9BV20 |
| NCBI GenInfo Identifier: | 74733279 |
| NCBI Gene ID: | 84245 |
| NCBI Accession: | Q9BV20.1 |
| UniProt Secondary Accession: | Q9BV20,Q8NDC9, |
| UniProt Related Accession: | Q9BV20 |
| Molecular Weight: | 34,529 Da |
| NCBI Full Name: | Methylthioribose-1-phosphate isomerase |
| NCBI Synonym Full Names: | methylthioribose-1-phosphate isomerase 1 |
| NCBI Official Symbol: | MRI1 |
| NCBI Official Synonym Symbols: | M1Pi; MRDI; MTNA; Ypr118w |
| NCBI Protein Information: | methylthioribose-1-phosphate isomerase |
| UniProt Protein Name: | Methylthioribose-1-phosphate isomerase |
| UniProt Synonym Protein Names: | Mediator of RhoA-dependent invasion; S-methyl-5-thioribose-1-phosphate isomerase |
| Protein Family: | Methylthioribose-1-phosphate isomerase |
| UniProt Gene Name: | MRI1 |
| UniProt Entry Name: | MTNA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MRI1 antibody (CAB14344) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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