Anti-MPP7 Antibody (CAB16598)
- SKU:
- CAB16598
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MPP7 Antibody |
| Antibody SKU: | CAB16598 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 297-576 of human MPP7 (NP_775767.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 297-576 of human MPP7 (NP_775767.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RLAL RRPE ILVQ PLKV SNRK SSGF RKSF RLSR KDKK TNKS MYEC KKSD QYDT ADVP TYEE VTPY RRQT NEKY RLVV LVGP VGVG LNEL KRKL LISD TQHY GVTV PHTT RARR SQES DGVE YIFI SKHL FETD VQNN KFIE YGEY KNNY YGTS IDSV RSVL AKNK VCLL DVQP HTVK HLRT LEFK PYVI FIKP PSIE RLRE TRKN AKII SSRD DQGA AKPF TEED FQEM IKSA QIME SQYG HLFD KIII NDDL TVAF NELK TTFD KLET ETHW VPVS WLHS |
| Gene ID: | 143098 |
| Uniprot: | Q5T2T1 |
| Cellular Location: | Cell junction, Membrane, Peripheral membrane protein, adherens junction, tight junction |
| Calculated MW: | 42kDa/65kDa |
| Observed MW: | 55kDa |
| Synonyms: | MPP7 |
| Background: | The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | MPP7: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. Belongs to the MAGUK family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 10p12.1 Cellular Component: adherens junction; tight junction; mitochondrion; cell junction Molecular Function:protein domain specific binding; protein binding; protein heterodimerization activity; protein complex scaffold Biological Process: positive regulation of protein complex assembly; positive regulation of signal transduction; establishment of cell polarity |
| NCBI Summary: | The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q5T2T1 |
| NCBI GenInfo Identifier: | 74762233 |
| NCBI Gene ID: | 143098 |
| NCBI Accession: | Q5T2T1.1 |
| UniProt Related Accession: | Q5T2T1 |
| Molecular Weight: | |
| NCBI Full Name: | MAGUK p55 subfamily member 7 |
| NCBI Synonym Full Names: | membrane palmitoylated protein 7 |
| NCBI Official Symbol: | MPP7 |
| NCBI Protein Information: | MAGUK p55 subfamily member 7 |
| UniProt Protein Name: | MAGUK p55 subfamily member 7 |
| Protein Family: | MAGUK p55 subfamily |
| UniProt Gene Name: | MPP7 |
| UniProt Entry Name: | MPP7_HUMAN |
 | Western blot analysis of extracts of mouse lung, using MPP7 antibody (CAB16598) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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