Anti-Mouse PD-1 Antibody [RMP1-14] In Vivo - Low Endotoxin
![Anti-Mouse PD-1 Antibody [RMP1-14] In Vivo - Low Endotoxin](https://cdn11.bigcommerce.com/s-39x6lpnvxv/images/stencil/608x608/products/119785/117968/anti-mouse-pd-1-cd279-rmp1-14-in-vivo-antibody-low-endotoxin__18202__65875.1698937710.jpg?c=1 "Anti-Mouse PD-1 Antibody [RMP1-14] In Vivo - Low Endotoxin")
- SKU:
- IVMB0037
- Product Type:
- In Vivo Monoclonal Antibody
- Clone:
- RMP1-14
- Protein:
- PD-1
- Isotype:
- Rat IgG2a kappa
- Reactivity:
- Mouse
- Synonyms:
- Programmed Death-1
- CD279
- PD 1
- Research Area:
- Immune Checkpoint & Cancer Biology
- Endotoxin Level:
- Low Endotoxin
- Host Species:
- Rat
- Applications:
- Blocking
- FA
- WB
![Anti-Mouse PD-1 Antibody [RMP1-14] In Vivo - Low Endotoxin](https://cdn11.bigcommerce.com/s-39x6lpnvxv/images/stencil/1280x1280/products/119785/117968/anti-mouse-pd-1-cd279-rmp1-14-in-vivo-antibody-low-endotoxin__18202__65875.1698937710.jpg?c=1&imbypass=on "Anti-Mouse PD-1 Antibody [RMP1-14] In Vivo - Low Endotoxin")
Description
| Product Name: | Anti-Mouse PD-1 (CD279) [RMP1-14] In Vivo Antibody - Low Endotoxin |
| Product Code: | IVMB0037 |
| Size: | 1mg, 5mg, 25mg, 50mg, 100mg |
| Clone: | RMP1-14 |
| Protein: | PD-1 |
| Product Type: | Monoclonal Antibody |
| Synonyms: | Programmed Death-1, CD279, PD 1 |
| Isotype: | Rat IgG2a κ |
| Reactivity: | Mouse |
| Immunogen: | Mouse PD-1 transfected BHK cells |
| Applications: | B, FA, WB |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | B, FA, WB |
| Reactivity: | Mouse |
| Host Species: | Rat |
| Specificity: | Clone RMP1-14 recognizes an epitope on mouse PD-1. |
| Antigen Distribution: | PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. |
| Immunogen: | Mouse PD-1 transfected BHK cells |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
PD-1 is a 50-55 kD member of the B7 Ig superfamily. PD-1 is also a member of the extended CD28/CTLA-4 family of T cell regulators and is suspected to play a role in lymphocyte clonal selection and peripheral tolerance. The ligands of PD-1 are PD-L1 and PD-L2, and are also members of the B7 Ig superfamily. PD-1 and its ligands negatively regulate immune responses. PD-L1, or B7-Homolog 1, is a 40 kD type I transmembrane protein that has been reported to costimulate T cell growth and cytokine production. The interaction of PD-1 with its ligand PD-L1 is critical in the inhibition of T cell responses that include T cell proliferation and cytokine production. PD-L1 has increased expression in several cancers. Inhibition of the interaction between PD-1 and PD-L1 can serve as an immune checkpoint blockade by improving T-cell responses In vitro and mediating preclinical antitumor activity. Within the field of checkpoint inhibition, combination therapy using anti-PD1 in conjunction with anti-CTLA4 has significant therapeutic potential for tumor treatments. PD-L2 is a 25 kD type I transmembrane ligand of PD-1. Via PD-1, PD-L2 can serve as a co-inhibitor of T cell functions. Regulation of T cell responses, including enhanced T cell proliferation and cytokine production, can result from mAbs that block the PD-L2 and PD-1 interaction.
| Technical Datasheet: | View |
| Protein: | PD-1 |
| Function: | Lymphocyte clonal selection, peripheral tolerance |
| Ligand/Receptor: | PD-L1 (B7-H1), PD-L2 |
| Research Area: | Apoptosis, Cancer, Cell Biology, Cell Death, Immunology, Inhibitory Molecules, Tumor Suppressors |
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