Anti-Mouse IL-2 [JES6-1A12] In Vivo Antibody - Low Endotoxin

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SKU:
IVMB0024
Product Type:
In Vivo Monoclonal Antibody
Clone:
JES6-1A12
Protein:
IL-2
Isotype:
Rat IgG2a kappa
Reactivity:
Mouse
Synonyms:
TCGF
Lymphokine
T-Cell Growth Factor
Research Area:
Cytokines, Chemokines & Receptors
Endotoxin Level:
Low Endotoxin
Host Species:
Rat
Applications:
IP
Neutralizing
WB
Frequently bought together:

Description

system_update_altTechnical Datasheet
Product Name:Anti-Mouse IL-2 [JES6-1A12] In Vivo Antibody - Low Endotoxin
Product Code:IVMB0024
Size:1mg
Clone:JES6-1A12
Protein:IL-2
Product Type:Monoclonal Antibody
Synonyms:TCGF, Lymphokine, T-Cell Growth Factor
Isotype:Rat IgG2a κ
Reactivity:Mouse
Immunogen:Purified Recombinant Mouse IL-2 (>98%)
Applications:IP, N, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:IP, N, WB
Reactivity:Mouse
Host Species:Rat
Specificity:Clone JES6-1A12 recognizes an epitope on mouse IL-2.
Immunogen:Purified Recombinant Mouse IL-2 (>98%)
Concentration:≥ 5.0 mg/ml
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

IL-2 is a 17.2 kD cytokine signaling protein that is the regulator of the proliferative and suppressive phases of the immune response, and stimulates growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes. It functions as a primary regulator of T cell homeostasis. Il-2 regulates the activities of white blood cells and plays a role in the immune system via “self” and “non-self” discrimination. IL-2 is a prime candidate in immunotherapeutics for both increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. IL-2 signal can be transduced via 3 different signaling pathways that include the JAK-STAT, PI3K/Akt/mTOR and MAPK/ERK pathways. Aldesleukin is a form of recombinant interleukin-2 for the treatment of cancers including malignant melanoma and renal cell cancer. Furthermore, there is additional therapeutic potential for IL-2 mAb use with transplants and autoimmune disease.

Technical Datasheet:View
Protein:IL-2
Ligand/Receptor:High affinity heterotrimer of IL-2Rα/β/γ, intermediate affinity homodimer IL-2Rα (CD25; p55; Tac) and heterodimer IL-2Rβ (CD122)/γ; γ-subunit (CD132) in common with IL-4R, IL-7R, IL-13R, IL-15R
Research Area:Immunology
Product Thumbnail
Rat IgG2a Isotype Control
Clone 1-1
Isotype Rat IgG2a
Endotoxin Level Low Endotoxin
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