Anti-Mouse IL-1α In Vivo Antibody - Low Endotoxin

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SKU:
IVMB0005
Product Type:
In Vivo Monoclonal Antibody
Clone:
ALF-161
Protein:
Interleukin-1 Alpha
Isotype:
Armenian Hamster IgG1
Reactivity:
Mouse
Synonyms:
Hematopoietin-1
Lymphocyte-activating factor (LAF)
Endogenous Pyrogen (EP)
Leukocyte Endogenous Mediator (LEM)
Mononuclear Cell Factor (MCF)
Research Area:
Cytokines, Chemokines & Receptors
Endotoxin Level:
Low Endotoxin
Host Species:
Armenian Hamster
Applications:
Neutralizing
WB
Frequently bought together:

Description

system_update_altTechnical Datasheet
Product Name:Anti-Mouse IL-1α In Vivo Antibody - Low Endotoxin
Product Code:IVMB0005
Size:1mg, 5mg, 25mg, 50mg, 100mg
Clone:ALF-161
Protein:Interleukin-1 Alpha
Product Type:Monoclonal Antibody
Synonyms:Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Isotype:Armenian Hamster IgG1
Reactivity:Mouse
Immunogen:Recombinant mouse IL-1α
Applications:N, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:N, WB
Reactivity:Mouse
Host Species:Armenian Hamster
Specificity: Anti-Mouse IL-1α recognizes Mouse IL-1α. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Immunogen:Recombinant mouse IL-1α
Concentration:≥ 5.0 mg/ml
Endotoxin Level:< 1.0 EU/mg as determined by the LAL method
Purity:≥95% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Mouse IL-1alpha is a non-secreted proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine.

Technical Datasheet:View
Protein:Interleukin-1 Alpha
Research Area:Immunology, Innate Immunity

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