Anti-Mouse CD278 (ICOS) In Vivo Antibody - Ultra Low Endotoxin

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SKU:
IVMB0083
Product Type:
In Vivo Monoclonal Antibody
Clone:
7E.17G9
Protein:
CD278
Isotype:
Rat IgG2b
Reactivity:
Mouse
Synonyms:
Inducible Costimulator,ICOS
Research Area:
Immune Checkpoint & Cancer Biology
Endotoxin Level:
Ultra Low Endotoxin
Host Species:
Rat
Applications:
Blocking
FA
WB
Frequently bought together:

Description

system_update_altTechnical Datasheet
Product Name:Anti-Mouse CD278 (ICOS) In Vivo Antibody - Ultra Low Endotoxin
Product Code:IVMB0083
Size:1mg, 5mg, 25mg, 50mg, 100mg
Clone:7E.17G9
Protein:CD278
Product Type:Monoclonal Antibody
Synonyms:Inducible Costimulator,ICOS
Isotype:Rat IgG2b
Reactivity:Mouse
Immunogen:Mouse ICOS cDNA and ICOS hexahistidine fusion protein
Applications:B, FA, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:<0.5 EU/mg as determined by the LAL method
Purity:≥98% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Product CodeProduct NameEndotoxin Level
IVMB0082Anti-Mouse CD278 (ICOS) In Vivo Antibody - Low EndotoxinLow
IVMB0083Anti-Mouse CD278 (ICOS) In Vivo Antibody - Ultra Low EndotoxinUltra Low
Applications:B, FA, WB
Reactivity:Mouse
Host Species:Rat
Specificity:Clone 7E.17G9 recognizes an epitope on mouse CD278.
Antigen Distribution:ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.
Immunogen:Mouse ICOS cDNA and ICOS hexahistidine fusion protein
Concentration:≥ 5.0 mg/ml
Endotoxin Level:<0.5 EU/mg as determined by the LAL method
Purity:≥98% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.

Technical Datasheet:View
Protein:CD278
Ligand/Receptor:B7h/B7RP-1/GL-50
Research Area:Costimulatory Molecules, Immunology
Product Thumbnail
Rat IgG2b Isotype Control
Clone 1-2
Isotype Rat IgG2b kappa
Endotoxin Level Ultra Low Endotoxin
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