Anti-MOG Antibody (CAB5353)
- SKU:
- CAB5353
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MOG Antibody |
| Antibody SKU: | CAB5353 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-154 of human MOG (NP_996532.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-154 of human MOG (NP_996532.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GQFR VIGP RHPI RALV GDEV ELPC RISP GKNA TGME VGWY RPPF SRVV HLYR NGKD QDGD QAPE YRGR TELL KDAI GEGK VTLR IRNV RFSD EGGF TCFF RDHS YQEE AAME LKVE DPFY WVSP G |
| Gene ID: | 4340 |
| Uniprot: | Q16653 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein, Single-pass type I membrane protein |
| Calculated MW: | 12- 14kDa/19-33kDa |
| Observed MW: | 28kDa |
| Synonyms: | MOG, BTN6, BTNL11, MOGIG2, NRCLP7 |
| Background: | The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | MOG: Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7). Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Belongs to the immunoglobulin superfamily. BTN/MOG family. 10 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 6p22.1 Cellular Component: integral to membrane; plasma membrane Biological Process: central nervous system development; positive regulation of MyD88-dependent toll-like receptor signaling pathway; cell adhesion Disease: Narcolepsy 7 |
| NCBI Summary: | The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16653 |
| NCBI GenInfo Identifier: | 317373391 |
| NCBI Gene ID: | 4340 |
| NCBI Accession: | Q16653.2 |
| UniProt Secondary Accession: | Q16653,O00713, O00714, O00715, Q13054, Q13055, A6NDR4 A6NNJ9, A8MY31, B0UZR9, E9PGF0, F8W9D5, |
| UniProt Related Accession: | Q16653 |
| Molecular Weight: | 247 |
| NCBI Full Name: | Myelin-oligodendrocyte glycoprotein |
| NCBI Synonym Full Names: | myelin oligodendrocyte glycoprotein |
| NCBI Official Symbol: | MOG |
| NCBI Official Synonym Symbols: | BTN6; BTNL11; MOGIG2; NRCLP7 |
| NCBI Protein Information: | myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; MOG alpha-5 |
| UniProt Protein Name: | Myelin-oligodendrocyte glycoprotein |
| Protein Family: | Molybdopterin adenylyltransferase |
| UniProt Gene Name: | MOG |
| UniProt Entry Name: | MOG_HUMAN |
 | Western blot analysis of extracts of mouse brain, using MOG antibody (CAB5353) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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