Anti-MMP11 Antibody (CAB3034)
- SKU:
- CAB3034
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MMP11 Antibody |
| Antibody SKU: | CAB3034 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human MMP11 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, 293T, Mouse lung, Mouse kidney, Mouse skeletal muscle, Mouse ovary, Mouse heart |
| Immunogen: | A synthetic peptide of human MMP11 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4320 |
| Uniprot: | P24347 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 54kDa |
| Observed MW: | 60kDa |
| Synonyms: | MMP11, SL-3, ST3, STMY3 |
| Background: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. |
| UniProt Protein Function: | MMP11: May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:Extracellular matrix; Protease; Secreted; EC 3.4.24.-; Secreted, signal peptide Chromosomal Location of Human Ortholog: 22q11.23 Cellular Component: extracellular region; Golgi lumen; proteinaceous extracellular matrix Molecular Function:serine-type endopeptidase activity Biological Process: collagen catabolic process; extracellular matrix disassembly |
| NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P24347 |
| NCBI GenInfo Identifier: | 317373418 |
| NCBI Gene ID: | 4320 |
| NCBI Accession: | P24347.3 |
| UniProt Secondary Accession: | P24347,Q5FX24, Q6PEZ6, Q9UC26, |
| UniProt Related Accession: | P24347 |
| Molecular Weight: | 54,590 Da |
| NCBI Full Name: | Stromelysin-3 |
| NCBI Synonym Full Names: | matrix metallopeptidase 11 |
| NCBI Official Symbol: | MMP11 |
| NCBI Official Synonym Symbols: | ST3; SL-3; STMY3 |
| NCBI Protein Information: | stromelysin-3 |
| UniProt Protein Name: | Stromelysin-3 |
| UniProt Synonym Protein Names: | Matrix metalloproteinase-11; MMP-11 |
| Protein Family: | Stromelysin |
| UniProt Gene Name: | MMP11 |
| UniProt Entry Name: | MMP11_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MMP11 antibody (CAB3034) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 2min. |
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