Anti-MLLT10 Antibody (CAB14260)
- SKU:
- CAB14260
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-MLLT10 Antibody |
| Antibody SKU: | CAB14260 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human MLLT10 (NP_001182555.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T, Mouse spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human MLLT10 (NP_001182555.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EPSP ALVP SLTV TTEK TYTS TSNN SISG SLKR LEDT TARF TNAN FQEV SAHT SSGK DVSE TRGS EGKG KKSS AHSS GQRG RKPG GGRN PGTT VSAA SPFP QGSF SGTP GSVK SSSG SSVQ SPQD FLSF TDSD LRND SYSH SQQS SATK DVHK GESG SQEG GVNS FSTL IGLP STSA VTSQ PKSF ENSP GDLG NSSL PTAG YKRA QTSG IEEE TVKE KKRK GNKQ SKHG PGRP KGNK NQEN VSHL SVSS ASP |
| Gene ID: | 8028 |
| Uniprot: | P55197 |
| Cellular Location: | Nucleus |
| Calculated MW: | 13kDa/20kDa/109kDa/113kDa |
| Observed MW: | 113kDa |
| Synonyms: | MLLT10, AF10 |
| Background: | This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MLLT10: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 10p12 Cellular Component: cytoplasm; nucleoplasm Molecular Function:protein binding Biological Process: positive regulation of transcription from RNA polymerase II promoter Disease: Leukemia, Acute Myeloid |
| NCBI Summary: | This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] |
| UniProt Code: | P55197 |
| NCBI GenInfo Identifier: | 527504034 |
| NCBI Gene ID: | 8028 |
| NCBI Accession: | P55197.2 |
| UniProt Secondary Accession: | P55197,Q5JT37, Q5VX90, Q66K63, B1ANA8, |
| UniProt Related Accession: | P55197 |
| Molecular Weight: | 20,047 Da |
| NCBI Full Name: | Protein AF-10 |
| NCBI Synonym Full Names: | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 |
| NCBI Official Symbol: | MLLT10 |
| NCBI Official Synonym Symbols: | AF10 |
| NCBI Protein Information: | protein AF-10 |
| UniProt Protein Name: | Protein AF-10 |
| UniProt Synonym Protein Names: | ALL1-fused gene from chromosome 10 protein |
| Protein Family: | Protein |
| UniProt Gene Name: | MLLT10 |
| UniProt Entry Name: | AF10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MLLT10 antibody (CAB14260) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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