Anti-MLKL Antibody (CAB13452)

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SKU:
CAB13452
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-MLKL Antibody
Antibody SKU:CAB13452
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of mouse MLKL (NP_001297542.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of mouse MLKL (NP_001297542.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:EGCD SKKI RELV AEDK KQEP VGQD CPEL LREI INEC RAHE PSQR PSVD GRSL SGRE RILE RLSA VEES TDKK V
Gene ID:74568
Uniprot:
Cellular Location:Cell membrane, Cytoplasm
Calculated MW:53kDa/54kDa
Observed MW:Refer to figures
Synonyms:MLKL, hMLKL
Background:This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
Anti-MLKL Antibody (CAB13452)Immunohistochemistry of paraffin-embedded human tonsil using MLKL antibody (CAB13452) at dilution of 1:100 (40x lens).
Anti-MLKL Antibody (CAB13452)Immunohistochemistry of paraffin-embedded human breast cancer using MLKL antibody (CAB13452) at dilution of 1:100 (40x lens).
Anti-MLKL Antibody (CAB13452)Immunohistochemistry of paraffin-embedded human uterine cancer using MLKL antibody (CAB13452) at dilution of 1:100 (40x lens).

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