Anti-MKNK1 Antibody (CAB18429)
- SKU:
- CAB18429
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-MKNK1 Antibody |
| Antibody SKU: | CAB18429 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human MKNK1. |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, HepG2, Mouse pancreas, Rat skeletal muscle |
| Immunogen: | Recombinant protein of human MKNK1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8569 |
| Uniprot: | Q9BUB5 |
| Cellular Location: | Cytoplasm, Cytoplasm, Nucleus |
| Calculated MW: | 39kDa/47kDa/51kDa |
| Observed MW: | 51kDa |
 | Western blot - MKNK1 Rabbit pAb (CAB18429) |
| Synonyms: | MNK1, MKNK1 |
| Background: | This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. |
| UniProt Protein Function: | Mnk1: a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Translation; Protein kinase, CAMK; CAMK group; MAPKAPK family; MNK subfamily Chromosomal Location of Human Ortholog: 1p33 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; protein binding; protein serine/threonine kinase activity Biological Process: fibroblast growth factor receptor signaling pathway; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translational initiation |
| NCBI Summary: | This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q9BUB5 |
| NCBI GenInfo Identifier: | 30316115 |
| NCBI Gene ID: | 8569 |
| NCBI Accession: | Q9BUB5.1 |
| UniProt Secondary Accession: | Q9BUB5,O00312, Q5TC06, Q5TC07, Q6V0N6, D3DQ20, D3DQ21 |
| UniProt Related Accession: | Q9BUB5 |
| Molecular Weight: | 39,104 Da |
| NCBI Full Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
| NCBI Synonym Full Names: | MAP kinase interacting serine/threonine kinase 1 |
| NCBI Official Symbol: | MKNK1 |
| NCBI Official Synonym Symbols: | MNK1 |
| NCBI Protein Information: | MAP kinase-interacting serine/threonine-protein kinase 1 |
| UniProt Protein Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
| UniProt Synonym Protein Names: | MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1 |
| Protein Family: | MAP kinase-interacting serine/threonine-protein kinase |
| UniProt Gene Name: | MKNK1 |
| UniProt Entry Name: | MKNK1_HUMAN |