Anti-MIIP Antibody (CAB14417)
- SKU:
- CAB14417
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MIIP Antibody |
| Antibody SKU: | CAB14417 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 279-388 of human MIIP (NP_068752.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 279-388 of human MIIP (NP_068752.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AHVR VSIP LSIL EPPH RYHI HRRK SFDA SDTL ALPR HCLL GWDI FPPK SEKS SAPR NLDL WSSV SAEA QHQK LSGT SSPF HPAS PMQM LPPT PTWS VPQV PRPH VPRQ KP |
| Gene ID: | 60672 |
| Uniprot: | Q5JXC2 |
| Cellular Location: | |
| Calculated MW: | 39kDa/42kDa |
| Observed MW: | 43kDa |
| Synonyms: | MIIP, IIP45 |
| Background: | This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. |
| UniProt Protein Function: | MIIP: Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1p36.22 Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q5JXC2 |
| NCBI GenInfo Identifier: | 296439302 |
| NCBI Gene ID: | 60672 |
| NCBI Accession: | Q5JXC2.3 |
| UniProt Secondary Accession: | Q5JXC2,Q96HU6, Q9H839, Q9HA00, C0KL22, |
| UniProt Related Accession: | Q5JXC2 |
| Molecular Weight: | 39,292 Da |
| NCBI Full Name: | Migration and invasion-inhibitory protein |
| NCBI Synonym Full Names: | migration and invasion inhibitory protein |
| NCBI Official Symbol: | MIIP |
| NCBI Official Synonym Symbols: | IIP45 |
| NCBI Protein Information: | migration and invasion-inhibitory protein |
| UniProt Protein Name: | Migration and invasion-inhibitory protein |
| UniProt Synonym Protein Names: | IGFBP2-binding protein; Invasion-inhibitory protein 45; IIp45 |
| Protein Family: | Migration and invasion-inhibitory protein |
| UniProt Gene Name: | MIIP |
| UniProt Entry Name: | MIIP_HUMAN |
 | Western blot analysis of extracts of HeLa cells, using MIIP antibody (CAB14417) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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