Anti-MGST2 Antibody (CAB16400)
- SKU:
- CAB16400
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-MGST2 Antibody |
| Antibody SKU: | CAB16400 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human MGST2 (NP_002404.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | U-937, PC-12 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human MGST2 (NP_002404.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | FRAQ QNCV EFYP IFII TLWM AGWY FNQV FATC LGLV YIYG RHLY FWGY SEAA KKRI TGFR LSLG ILAL LTLL GALG IANS FLDE YLDL NIAK KLRR QF |
| Gene ID: | 4258 |
| Uniprot: | Q99735 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Multi-pass membrane protein |
| Calculated MW: | 8kDa/16kDa |
| Observed MW: | 17kDa |
| Synonyms: | MGST2, GST2, MGST-II |
| Background: | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |
| UniProt Protein Function: | MGST2: Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione. Belongs to the MAPEG family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transferase; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Endoplasmic reticulum; EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450 Chromosomal Location of Human Ortholog: 4q28.3 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bound organelle; nuclear envelope; plasma membrane Molecular Function:glutathione peroxidase activity; glutathione transferase activity; leukotriene-C4 synthase activity Biological Process: glutathione biosynthetic process; leukotriene biosynthetic process; xenobiotic metabolic process |
| NCBI Summary: | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011] |
| UniProt Code: | Q99735 |
| NCBI GenInfo Identifier: | 2842764 |
| NCBI Gene ID: | 4258 |
| NCBI Accession: | Q99735.1 |
| UniProt Secondary Accession: | Q99735,Q7Z5B8, D6RBB5, |
| UniProt Related Accession: | Q99735 |
| Molecular Weight: | 8,359 Da |
| NCBI Full Name: | Microsomal glutathione S-transferase 2 |
| NCBI Synonym Full Names: | microsomal glutathione S-transferase 2 |
| NCBI Official Symbol: | MGST2 |
| NCBI Official Synonym Symbols: | GST2; MGST-II |
| NCBI Protein Information: | microsomal glutathione S-transferase 2 |
| UniProt Protein Name: | Microsomal glutathione S-transferase 2 |
| UniProt Synonym Protein Names: | Microsomal GST-II |
| Protein Family: | Microsomal glutathione S-transferase |
| UniProt Gene Name: | MGST2 |
| UniProt Entry Name: | MGST2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MGST2 antibody (CAB16400) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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