Anti-MGST1 Antibody (CAB16399)
- SKU:
- CAB16399
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MGST1 Antibody |
| Antibody SKU: | CAB16399 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MGST1 (NP_001247440.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MGST1 (NP_001247440.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MVDL TQVM DDEV FMAF ASYA TIIL SKMM LMST ATAF YRLT RKVF ANPE DCVA FGKG ENAK KYLR TDDR VERV RRAH LNDL ENII PFLG IGLL YSLS GPDP |
| Gene ID: | 4257 |
| Uniprot: | P10620 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome, Mitochondrion outer membrane, Multi-pass membrane protein, Peripheral membrane protein |
| Calculated MW: | 9kDa/17kDa |
| Observed MW: | 18kDa |
| Synonyms: | MGST1, GST12, MGST, MGST-I |
| Background: | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. |
| UniProt Protein Function: | MGST1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity. Belongs to the MAPEG family. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - metabolism by cytochrome P450; Mitochondrial; EC 2.5.1.18; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Membrane protein, multi-pass; Membrane protein, integral; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 12p12.3-p12.1 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; mitochondrion; peroxisomal membrane Molecular Function:glutathione peroxidase activity; glutathione transferase activity; protein binding Biological Process: xenobiotic metabolic process |
| NCBI Summary: | The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012] |
| UniProt Code: | P10620 |
| NCBI GenInfo Identifier: | 121740 |
| NCBI Gene ID: | 4257 |
| NCBI Accession: | P10620.1 |
| UniProt Secondary Accession: | P10620,A8K533, G5EA53, |
| UniProt Related Accession: | P10620 |
| Molecular Weight: | 9,984 Da |
| NCBI Full Name: | Microsomal glutathione S-transferase 1 |
| NCBI Synonym Full Names: | microsomal glutathione S-transferase 1 |
| NCBI Official Symbol: | MGST1 |
| NCBI Official Synonym Symbols: | MGST; GST12; MGST-I |
| NCBI Protein Information: | microsomal glutathione S-transferase 1 |
| UniProt Protein Name: | Microsomal glutathione S-transferase 1 |
| UniProt Synonym Protein Names: | Microsomal GST-I |
| Protein Family: | Microsomal glutathione S-transferase |
| UniProt Gene Name: | MGST1 |
| UniProt Entry Name: | MGST1_HUMAN |
 | Western blot analysis of extracts of mouse lung, using MGST1 antibody (CAB16399) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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