Anti-MGLL Antibody (CAB6654)
- SKU:
- CAB6654
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-MGLL Antibody |
| Antibody SKU: | CAB6654 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human MGLL (NP_009214.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, A-549, SH-SY5Y, Mouse heart, Rat brain, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human MGLL (NP_009214.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | METG PEDP SSMP EESS PRRT PQSI PYQD LPHL VNAD GQYL FCRY WKPT GTPK ALIF VSHG AGEH SGRY EELA RMLM GLDL LVFA HDHV GHGQ SEGE RMVV SDFH VFVR DVLQ HVDS MQKD YPGL PVFL LGHS MGGA IAIL TAAE RPGH FAGM VLIS PLVL ANPE SATT FKVL AAKV LNLV LPNL SLGP IDSS VLSR NKTE VDIY NSDP LICR AGLK VCFG IQLL NAVS RVER ALPK LTVP FLLL QGSA DRLC DSKG AYLL MELA KSQD KTLK IYEG AYHV LHKE LPEV TNSV FHEI NMWV SQR |
| Gene ID: | 11343 |
| Uniprot: | Q99685 |
| Cellular Location: | Cytoplasm, Membrane, Peripheral membrane protein, cytosol |
| Calculated MW: | 31kDa/33kDa |
| Observed MW: | 33KDa |
| Synonyms: | MGLL, HU-K5, HUK5, MAGL, MGL |
| Background: | This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | MGLL: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family. |
| UniProt Protein Details: | Protein type:Phospholipase; EC 3.1.1.23; Lipid Metabolism - glycerolipid Chromosomal Location of Human Ortholog: 3q21.3 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; extrinsic to membrane; plasma membrane; synapse; cytosol Molecular Function:protein homodimerization activity; acylglycerol lipase activity; lipid binding; lysophospholipase activity Biological Process: platelet activation; glycerophospholipid biosynthetic process; regulation of signal transduction; regulation of axon extension; phospholipid metabolic process; triacylglycerol catabolic process; regulation of inflammatory response; arachidonic acid metabolic process; lipid metabolic process; regulation of sensory perception of pain; inflammatory response; blood coagulation; fatty acid biosynthetic process; acylglycerol catabolic process |
| NCBI Summary: | This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q99685 |
| NCBI GenInfo Identifier: | 47117287 |
| NCBI Gene ID: | 11343 |
| NCBI Accession: | Q99685.2 |
| UniProt Secondary Accession: | Q99685,Q6IBG9, Q96AA5, B3KRC2, B7Z9D1, |
| UniProt Related Accession: | Q99685 |
| Molecular Weight: | 303 |
| NCBI Full Name: | Monoglyceride lipase |
| NCBI Synonym Full Names: | monoglyceride lipase |
| NCBI Official Symbol: | MGLL |
| NCBI Official Synonym Symbols: | MGL; HUK5; MAGL; HU-K5 |
| NCBI Protein Information: | monoglyceride lipase; monoacylglycerol lipase; lysophospholipase homolog |
| UniProt Protein Name: | Monoglyceride lipase |
| UniProt Synonym Protein Names: | HU-K5; Lysophospholipase homolog; Lysophospholipase-like; Monoacylglycerol lipase; MAGL |
| Protein Family: | Monoglyceride lipase |
| UniProt Gene Name: | MGLL |
| UniProt Entry Name: | MGLL_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MGLL antibody (CAB6654) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Western blot analysis of extracts of Mouse heart, using MGLL antibody (CAB6654) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
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