Anti-MEF2D Antibody (CAB16398)
- SKU:
- CAB16398
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-MEF2D Antibody |
| Antibody SKU: | CAB16398 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 431-521 of human MEF2D (NP_005911.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-251MG, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 431-521 of human MEF2D (NP_005911.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TTHP HISI KSEP VSPS RERS PAPP PPAV FPAA RPEP GDGL SSPA GGSY ETGD RDDG RGDF GPTL GLLR PAPE PEAE GSAV KRMR LDTW TLK |
| Gene ID: | 4209 |
| Uniprot: | Q14814 |
| Cellular Location: | Nucleus |
| Calculated MW: | 49kDa/50kDa/55kDa/56kDa |
| Observed MW: | 70kDa |
| Synonyms: | MEF2D |
| Background: | This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | MEF2D: transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in muscle-specific and/or growth factor-related transcription. Six splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 1q12-q23 Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription activator binding; transcription factor activity Biological Process: adult heart development; apoptosis; chondrocyte differentiation; endochondral ossification; muscle development; nervous system development; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012] |
| UniProt Code: | Q14814 |
| NCBI GenInfo Identifier: | 2500876 |
| NCBI Gene ID: | 4209 |
| NCBI Accession: | Q14814.1 |
| UniProt Secondary Accession: | Q14814,Q14815, Q5T9U5, Q5T9U6, D3DVC0, |
| UniProt Related Accession: | Q14814 |
| Molecular Weight: | 49,856 Da |
| NCBI Full Name: | Myocyte-specific enhancer factor 2D |
| NCBI Synonym Full Names: | myocyte enhancer factor 2D |
| NCBI Official Symbol: | MEF2D |
| NCBI Protein Information: | myocyte-specific enhancer factor 2D |
| UniProt Protein Name: | Myocyte-specific enhancer factor 2D |
| Protein Family: | Myocyte-specific enhancer factor |
| UniProt Gene Name: | MEF2D |
| UniProt Entry Name: | MEF2D_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MEF2D antibody (CAB16398) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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