Anti-MED15 Antibody (CAB18238)
- SKU:
- CAB18238
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| Antibody Name: | Anti-MED15 Antibody |
| Antibody SKU: | CAB18238 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human MED15. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse heart, Mouse brain, Rat heart, Rat brain |
| Immunogen: | Recombinant protein of human MED15. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 51586 |
| Uniprot: | Q96RN5 |
| Cellular Location: | |
| Calculated MW: | 87kDa |
| Observed MW: | 87kDa |
 | Western blot - MED15 Polyclonal Antibody (CAB18238) |
| Synonyms: | MED15, ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7 |
| Background: | The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | PCQAP: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. Belongs to the Mediator complex subunit 15 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 22q11.2 Cellular Component: nucleoplasm; membrane; cytoplasm; Srb-mediator complex; nucleus Molecular Function:protein binding Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; stem cell maintenance; gene expression |
| NCBI Summary: | The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
| UniProt Code: | Q96RN5 |
| NCBI GenInfo Identifier: | 119623361 |
| NCBI Gene ID: | 51586 |
| NCBI Accession: | EAX02956.1 |
| UniProt Secondary Accession: | Q96RN5,O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3 D3DX31, D3DX32, |
| UniProt Related Accession: | Q96RN5 |
| Molecular Weight: | 86,753 Da |
| NCBI Full Name: | PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein, isoform CRA_d |
| NCBI Synonym Full Names: | mediator complex subunit 15 |
| NCBI Official Symbol: | MED15 |
| NCBI Official Synonym Symbols: | TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105 |
| NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 15; TPA inducible gene-1; CTG repeat protein 7a; TPA inducible protein; TPA-inducible gene 1 protein; trinucleotide repeat containing 7; activator-recruited cofactor, 105-kD; PC2-glutamine-rich-associated protein; PC2 glutamine/Q-rich-associated protein; activator-recruited cofactor 105 kDa component; trinucleotide repeat-containing gene 7 protein; positive cofactor 2 glutamine/Q-rich-associated protein; positive cofactor 2, glutamine/Q-rich-associated protein; PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein |
| UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 15 |
| UniProt Synonym Protein Names: | Activator-recruited cofactor 105 kDa component; ARC105; CTG repeat protein 7a; Mediator complex subunit 15; Positive cofactor 2 glutamine/Q-rich-associated protein; PC2 glutamine/Q-rich-associated protein; TPA-inducible gene 1 protein; TIG-1; Trinucleotide repeat-containing gene 7 protein |
| UniProt Gene Name: | MED15 |
| UniProt Entry Name: | MED15_HUMAN |
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