Anti-MCTS1 Antibody (CAB9061)

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SKU:
CAB9061
Product type:
Antibody
Application:
WB
Application:
IF
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-MCTS1 Antibody
Antibody SKU:CAB9061
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human MCTS1 (NP_054779.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human MCTS1 (NP_054779.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MFKK FDEK ENVS NCIQ LKTS VIKG IKNQ LIEQ FPGI EPWL NQIM PKKD PVKI VRCH EHIE ILTV NGEL LFFR QREG PFYP TLRL LHKY PFIL PHQQ VDKG AIKF VLSG ANIM CPGL TSPG AKLY PAAV DTIV AIMA EGKQ HALC VGVM KMSA EDIE KVNK GIGI ENIH YLND GLWH MKTY K
Gene ID:28985
Uniprot:Q9ULC4
Cellular Location:Cytoplasm
Calculated MW:19kDa/20kDa
Observed MW:20kDa
Synonyms:MCTS1, MCT-1, MCT1
Background:
UniProt Protein Function:MCTS1: Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma- irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Belongs to the MCTS1 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Tumor suppressor

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: cytoplasm; plasma membrane

Biological Process: formation of translation preinitiation complex; positive regulation of cell proliferation; ribosome disassembly

UniProt Code:Q9ULC4
NCBI GenInfo Identifier:74735052
NCBI Gene ID:28985
NCBI Accession:Q9ULC4.1
UniProt Secondary Accession:Q9ULC4,Q502X6, B4DGY2,
UniProt Related Accession:Q9ULC4
Molecular Weight:20,550 Da
NCBI Full Name:Malignant T-cell-amplified sequence 1
NCBI Synonym Full Names:MCTS1, re-initiation and release factor
NCBI Official Symbol:MCTS1  
NCBI Official Synonym Symbols:MCT1; MCT-1  
NCBI Protein Information:malignant T-cell-amplified sequence 1
UniProt Protein Name:Malignant T-cell-amplified sequence 1
UniProt Synonym Protein Names:Multiple copies T-cell malignancies
Protein Family:Malignant T-cell-amplified sequence
UniProt Gene Name:MCTS1  
UniProt Entry Name:MCTS1_HUMAN

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