Anti-MCL1 Antibody (CAB18001)[KO Validated]

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SKU:
CAB18001
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
Frequently bought together:

Description

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Antibody Name:Anti-MCL1 Antibody [KO Validated]
Antibody SKU:CAB18001
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human MCL1
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:A-549
Immunogen:A synthetic peptide of human MCL1
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4170
Uniprot:Q07820
Cellular Location:Cytoplasm, Membrane, Mitochondrion, Nucleus, Single-pass membrane protein, nucleoplasm
Calculated MW:28kDa/37kDa
Observed MW:40kDa
Anti-MCL1 Antibody [KO Validated] (CAB18001)Western blot analysis of extracts from normal (control) and MCL1 knockout (KO) A-549 cells, using MCL1 antibody (CAB18001) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Synonyms:MCL1, BCL2L3, EAT, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, MCL1
Background:This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
UniProt Protein Function:MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.
UniProt Protein Details:

Protein type:Inhibitor; Apoptosis; Mitochondrial; Channel, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrion; membrane; mitochondrial matrix; cytoplasm; integral to membrane; cytosol; nucleus

Molecular Function:protein binding; protein homodimerization activity; protein heterodimerization activity; protein channel activity; BH3 domain binding

Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; multicellular organismal development; cellular homeostasis; cell fate determination

NCBI Summary:This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
UniProt Code:Q07820
NCBI GenInfo Identifier:83304396
NCBI Gene ID:4170
NCBI Accession:Q07820.3
UniProt Secondary Accession:Q07820,Q9HD91, Q9NRQ3, Q9NRQ4, Q9UHR7, Q9UHR8, Q9UHR9 Q9UNJ1, B2R6B2, D3DV03, D3DV04,
UniProt Related Accession:Q07820
Molecular Weight:350
NCBI Full Name:Induced myeloid leukemia cell differentiation protein Mcl-1
NCBI Synonym Full Names:myeloid cell leukemia 1
NCBI Official Symbol:MCL1  
NCBI Official Synonym Symbols:TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT  
NCBI Protein Information:induced myeloid leukemia cell differentiation protein Mcl-1; bcl-2-like protein 3; myeloid cell leukemia ES; bcl-2-related protein EAT/mcl1; myeloid cell leukemia sequence 1 (BCL2-related)
UniProt Protein Name:Induced myeloid leukemia cell differentiation protein Mcl-1
UniProt Synonym Protein Names:Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT
Protein Family:Minichromosome loss protein
UniProt Gene Name:MCL1  
UniProt Entry Name:MCL1_HUMAN

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