Anti-MCAT Antibody (CAB15822)
- SKU:
- CAB15822
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-MCAT Antibody |
| Antibody SKU: | CAB15822 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 191-390 of human MCAT (NP_775738.3). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | LO2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 191-390 of human MCAT (NP_775738.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SGML SVLG QPQS KFNF ACLE AREH CKSL GIEN PVCE VSNY LFPD CRVI SGHQ EALR FLQK NSSK FHFR RTRM LPVS GAFH TRLM EPAV EPLT QALK AVDI KKPL VSVY SNVH AHRY RHPG HIHK LLAQ QLVS PVKW EQTM HAIY ERKK GRGF PQTF EVGP GRQL GAIL KSCN MQAW KSYS AVDV LQTL EHVD LDPQ EPPR |
| Gene ID: | 27349 |
| Uniprot: | Q8IVS2 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 19kDa/42kDa |
| Observed MW: | 43kDa |
| Synonyms: | MCAT, FASN2C, MCT, MCT1, MT, NET62, fabD |
| Background: | The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | MCAT: Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias. Belongs to the type II malonyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - fatty acid biosynthesis; EC 2.3.1.39; Transferase Chromosomal Location of Human Ortholog: 22q13.31 Cellular Component: mitochondrion Molecular Function:[acyl-carrier-protein] S-malonyltransferase activity; transferase activity Biological Process: fatty acid biosynthetic process; metabolic process |
| NCBI Summary: | The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q8IVS2 |
| NCBI GenInfo Identifier: | 48428076 |
| NCBI Gene ID: | 27349 |
| NCBI Accession: | Q8IVS2.2 |
| UniProt Secondary Accession: | Q8IVS2,O95510, O95511, B0QY72, |
| UniProt Related Accession: | Q8IVS2 |
| Molecular Weight: | 19,176 Da |
| NCBI Full Name: | Malonyl-CoA-acyl carrier protein transacylase, mitochondrial |
| NCBI Synonym Full Names: | malonyl-CoA-acyl carrier protein transacylase |
| NCBI Official Symbol: | MCAT |
| NCBI Official Synonym Symbols: | MT; MCT; fabD; NET62; FASN2C |
| NCBI Protein Information: | malonyl-CoA-acyl carrier protein transacylase, mitochondrial |
| UniProt Protein Name: | Malonyl-CoA-acyl carrier protein transacylase, mitochondrial |
| UniProt Synonym Protein Names: | Mitochondrial malonyl CoA:ACP acyltransferase; Mitochondrial malonyltransferase; [Acyl-carrier-protein] malonyltransferase |
| Protein Family: | Malonyl-CoA-acyl carrier protein transacylase |
| UniProt Gene Name: | MCAT |
| UniProt Entry Name: | FABD_HUMAN |
 | Western blot analysis of extracts of LO2 cells, using MCAT antibody (CAB15822) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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